| DORAMECTIN | |
| Chemical names: | 25-CYCLOHEXYL-5-O-DEMETHYL-25-DE(1-METHYLPROPYL)AVERMECTIN A1a | Synonyms: | DECTOMAX©; UK-67,994® | Functional class: | VETERINARY DRUG (ANTHELMINTHIC AGENT) | Latest evaluation: | 2004 | ADI: | 0-0.001 mg/kg bw (2002) | Comments/MRLs: | MRLs (expressed as doramectin) recommended in 1995 and 1999 were maintained: Muscle (cattle): 0.01 mg/kg; muscle (pigs): 0.005 mg/kg; liver (cattle and pigs): 0.1 mg/kg; kidney (cattle and pigs): 0.03 mg/kg; fat (cattle and pigs): 0.15 mg/kg. At the present meeting an MRL of 0.15 mg/kg was recommended for milk (cattle). The Committee noted that the discard time necessary to accommodate the reommended MRL in milk is unlikely to be consistent with good veterinary practice. | Report: | TRS 925-JECFA 62/15 | Residues: | FNP 41/16-JECFA 62/25 | Tox monograph: | FAS 49-JECFA 58/3 (2002) | Previous status: | 2002, TRS 911-JECFA 58/7, FNP 41/12-JECFA 52/27 (1999) FAS 49-JECFA 58/3. 0-0.001 mg/kg bw. THE MRLS RECOMMENDED AT THE FORTY-FIFTH MEETING (1995) AND THE FIFTY-SECOND MEETING (1999) WERE NOT RECONSIDERED AND WERE MAINTAINED. FU. MRL
1999, TRS 893-JECFA 52/15, FNP 41/12-JECFA 52/27, FAS 36-JECFA 45/3 (1995). 0-0.0005 mg/kg bw. MRLs (EXPRESSED AS PARENT DRUG): MUSCLE (CATTLE): 0.01 mg/kg; MUSCLE (PIGS): 0.005 mg/kg; LIVER (CATTLE AND PIGS): 0.1 mg/kg; KIDNEY (CATTLE AND PIGS): 0.03 mg/kg; FAT (CATTLE AND PIGS): 0.15 mg/kg. THE COMMITTEE DREW ATTENTION TO THE HIGH CONCENTRATION OF DORAMECTIN RESIDUES AT THE INJECTION SITES. THE MRLs FOR CATTLE WERE RECOMMENDED AT THE FORTY-FIFTH MEETING (1995). FU. MRL 1995, TRS 864-JECFA 45/10, FNP 41/8-JECFA 45/85, FAS 36-JECFA 45/3. 0-0.0005. MRLs (EXPRESSED AS PARENT DRUG): MUSCLE (CATTLE): 0.01; LIVER (CATTLE): 0.1; KIDNEY (CATTLE): 0.03; FAT (CATTLE): 0.15. THE COMMITTEE NOTED THE HIGH CONCENTRATION OF RESIDUES AT THE INJECTION SITE OVER A 35-DAY PERIOD AFTER SUBCUTANEOUS OR INTRAMUSCULAR ADMINISTRATION OF THE DRUG AT THE RECOMMENDED DOSE. FU. MRL |
| 23 Apr 05 | |
See Also:
Toxicological Abbreviations
Doramectin (JECFA Food Additives Series 49)
Doramectin (WHO Food Additives Series 36)