FAO Nutrition Meetings
Report Series No. 40A,B,C
WHO/Food Add./67.29
TOXICOLOGICAL EVALUATION OF SOME
ANTIMICROBIALS, ANTIOXIDANTS, EMULSIFIERS,
STABILIZERS, FLOUR-TREATMENT AGENTS, ACIDS AND BASES
The content of this document is the result of the deliberations of the
Joint FAO/WHO Expert Committee on Food Additives which met at Rome,
13-20 December, 19651 Geneva, 11-18 October, 19662
1 Ninth Report of the Joint FAO/WHO Expert Committee on Food
Additives, FAO Nutrition Meetings Report Series, 1966 No. 40;
Wld Hlth Org. techn. Rep. Ser., 1966, 339
2 Tenth Report of the Joint FAO/WHO Expert Committee on Food
Additives, FAO Nutrition Meetings Report Series, 1967, in press;
Food and Agriculture Organization of the United Nations
World Health Organization
1967
ISOPROPYL CITRATE MIXTURE
Definition A mixture consisting of approximately
27 per cent. monoisopropyl citrate
9 per cent. diisopropyl citrate
2 per cent. triisopropyl citrate
62 per cent. mono-and diglycerides
Description More readily soluble in oils than citric
acid.
Use As a sequestering agent in antioxidant
mixtures and in fatty foods.
Monoisopropyl Citrate
Chemical name Citric acid ester of 2-Propanol
Structural formula
CH2 - COOR
'
HO - C - COOR
'
CH2 - COOR
Where in the major component one R is
isopropyl and the remainder are
hydrogen.
Definition Monoisopropyl citrate is formed by
esterifying citric acid with 2-propanol
resulting in a mixture of mainly
monoisopropyl citrates with some di-and
triisopropyl citrate. The product is the
isopropyl citrate used to prepare the
mixture described above.
Description Monoisopropyl citrate is a viscous,
colourless syrup exhibiting some
crystallization upon standing.
Specifications for monoisopropyl citrate will appear as working
papers for the Fourth meeting of the Codex Committee on Food
Additives, September 1967, and will be available on request from the
Joint FAO/WHO Food Standards Branch (Codex Alimentarius) FAO, Rome.
Biological Data
For biological data on the isopropyl citrate mixture see the
Sixth Report of the joint FAO/WHO Committee on Food Additives.
Evaluation
Level causing no toxicological effect
Rat. 28 000 ppm in the diet, equivalent to 1400 mg/kg
body-weight/day.
Estimate of acceptable daily intake for man
mg/kg body-weight
Unconditional acceptance 0-7
Conditional acceptance 7-20