INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY

    WORLD HEALTH ORGANIZATION



    SUMMARY OF TOXICOLOGICAL DATA OF CERTAIN FOOD ADDITIVES
    AND CONTAMINANTS



    WHO FOOD ADDITIVES SERIES NO. 13






    The data contained in this document were examined by the
    Joint FAO/WHO Expert Committee on Food Additives*
    Rome, 3-12 April 1978




    Food and Agriculture Organization of the United Nations
    World Health Organization



    * Twenty-second Report of the Joint FAO/WHO Expert Committee on Food
    Additives, Geneva, 1978, WHO Technical Report Series No. 631

    QUINOLINE YELLOW

    Explanation

         This colour was evaluated by the Joint FAO/WHO Expert Committee
    on Food Additives in 1964, 1969, 1974, 1975 and 1977. The following
    additional study has become available.

    BIOLOGICAL DATA

    Special study on reproduction

         Groups of 20 female and 10 male rats were fed 0, 0.5, 5.0, 15.0
    and 50.0 mg/kg/day in the diet starting two weeks prior to first
    mating and continued through three successive generations, three, two
    and one litters per generation being produced respectively. Dams were
    allowed to deliver their offspring and raise them to weaning for all
    mating periods except F2c when half of the dams were sacrificed on
    day 19 of gestation and their uterine contents examined. Offspring
    from the various matings were autopsied at weaning or selected to
    become parents of the next generation. Five rats/sex/dose level from
    F1b parents and the F3a pups were subjected to gross pathological
    examination and selected tissues from the animals of the control and
    high dose groups were examined microscopically. No compound-related
    effects were observed in parental mortality, body weight, food
    consumption, mating, pregnancy and fertility rates, pup survival, pup
    body weight, reproductive parameters including numbers of embryos,
    corpora lutea, resorptions or necropsy findings. No gross or
    histological abnormalities were noted in the tissues of the F1b or
    F3a generation rats which could be attributed to colour consumption
    (Smith, 1973).

    REFERENCE

    Smith, J. M. (1973) A three generation reproduction study of quinoline
    yellow in rats. Unpublished report submitted to the Inter-Industry
    Colour Committee by Biodynamics Inc.

    See Also:
       Toxicological Abbreviations
       Quinoline yellow  (FAO Nutrition Meetings Report Series 46a)
       Quinoline yellow (WHO Food Additives Series 6)
       Quinoline Yellow (WHO Food Additives Series 8)
       Quinoline yellow (WHO Food Additives Series 19)
       QUINOLINE YELLOW (JECFA Evaluation)