ANNEX 4
RECOMMENDATIONS ON COMPOUNDS ON THE AGENDA
Acceptable Daily Intake (ADI)
for human beings and other
toxicological recommendations Recommended Maximum Residue Limit
(MRL)
Substances
Anthelminthic drugs
Closantel 0-0.03 mg per kg of body weight Edible tissues of sheep: 1.5 mg/kg
Bovine tissues: muscle: 0.5 mg/kg1
kidney: 2 mg/kg1
liver: 1 mg/kg1
Ivermectin 0-0.0002 mg per kg of body Liver (all species): 0.015 mg/kg
weight Fat (all species): 0.2 mg/kg
Levamisole 0-0.003 mg per kg of body Edible tissues and milk (all
weight2 species): 0.01 mg/kg1
Antimicrobial agents
Benzylpenicillin 0.03 mg per person per day3 Liver, kidney, and muscle (all
species): 0.05 mg/kg
Milk: 0.004 mg/kg
Oxytetracycline 0-0.003 mg per kg of body All species: muscle: 0.1 mg/kg
weight liver: 0.3 mg/kg
kidney: 0.6 mg/kg
fat: 0.01 mg/kg
milk: 0.1 mg/kg
eggs: 0.2 mg/kg
Growth promoters
Carbadox Limited acceptance of Swine liver: 0.03 mg/kg5
residues4 Swine muscle: 0.005 mg/kg5
Olaquindox Limited acceptance of No MRLs allocated7
residues6
Notes to Annex 2
1. Temporary MRL (See Annex 3).
2. Temporary acdeptance (see Annexes 3 and 4).
3. Daily intake of the parent drug should be kept below this level.
4. Insufficient information was available to establish an ADI. The Committee concluded
that residues resulting from the use of carbadox in pigs were acceptable provided that
the recommended MRLS are not exceeded.
5. Residues are based on the levels of, and expressed as, quinoxaline-2-carboxylic acid.
6. Insufficient information was available to establish an ADI. The Committee concluded
that residues resulting from the use of olaquindox in food-producing animals under
conditions of good practice in the use of veterinary drugs were temporarily acceptable
(see Annex 3).
7. MRLs were not established because insuficient information was available (see Annex 3).