ANNEX 4

        RECOMMENDATIONS ON COMPOUNDS ON THE AGENDA

                                                                                               
                          Acceptable Daily Intake (ADI) 
                          for human beings and other 
                          toxicological recommendations      Recommended Maximum Residue Limit
                                                             (MRL)
    Substances
                                                                                               

    Anthelminthic drugs

    Closantel             0-0.03 mg per kg of body weight    Edible tissues of sheep: 1.5 mg/kg
                                                             Bovine tissues: muscle: 0.5 mg/kg1
                                                             kidney: 2 mg/kg1
                                                             liver: 1 mg/kg1

    Ivermectin            0-0.0002 mg per kg of body         Liver (all species): 0.015 mg/kg
                          weight                             Fat (all species): 0.2 mg/kg

    Levamisole            0-0.003 mg per kg of body          Edible tissues and milk (all 
                          weight2                            species): 0.01 mg/kg1

    Antimicrobial agents

    Benzylpenicillin      0.03 mg per person per day3        Liver, kidney, and muscle (all 
                                                             species): 0.05 mg/kg
                                                             Milk: 0.004 mg/kg

    Oxytetracycline       0-0.003 mg per kg of body          All species: muscle: 0.1 mg/kg
                          weight                             liver: 0.3 mg/kg
                                                             kidney: 0.6 mg/kg
                                                             fat: 0.01 mg/kg
                                                             milk: 0.1 mg/kg
                                                             eggs: 0.2 mg/kg

    Growth promoters

    Carbadox              Limited acceptance of              Swine liver: 0.03 mg/kg5 
                          residues4                          Swine muscle: 0.005 mg/kg5

    Olaquindox            Limited acceptance of              No MRLs allocated7
                          residues6

                                                                                               

    Notes to Annex 2

    1.   Temporary MRL (See Annex 3).
    2.   Temporary acdeptance (see Annexes 3 and 4).
    3.   Daily intake of the parent drug should be kept below this level.
    4.   Insufficient information was available to establish an ADI.  The Committee concluded 
         that residues resulting from the use of carbadox in pigs were acceptable provided that
         the recommended MRLS are not exceeded.
    5.   Residues are based on the levels of, and expressed as, quinoxaline-2-carboxylic acid.
    6.   Insufficient information was available to establish an ADI.  The Committee concluded 
         that residues resulting from the use of olaquindox in food-producing animals under 
         conditions of good practice in the use of veterinary drugs were temporarily acceptable 
         (see Annex 3).
    7.   MRLs were not established because insuficient information was available (see Annex 3).

    See Also:
       Toxicological Abbreviations