ANNEX 2

    ABBREVIATIONS USED IN THE MONOGRAPHS

    AAF       acetylaminofluorine
    ADI       acceptable daily intake
    ALD       aldrin epoxidase
    AP        alkaline phosphatase

    BBN       N-butyl-N-(4-hydroxybutyl)nitrosamine
    BCF       bioconcentration factor
    BH        biphenyl-4-hydroxylase
    BHA       butylated hydroxyanisole
    BHT       butylated hydroxytoluene
    BHT-MeOH  2,6-di-tert-butyl-4-hydroxy-methylphenol
    BOS       buthionine sulfoximine
    BPDEI     benzo[a]pyrene-7,8-diol-9,10-oxide
    BUN       blood urea nitrogen
    b.w.      body weight

    4-CG      4-chlorogalactose
    CHO       chinese hamster ovary
    CNS       central nervous system

    DBQ       2,6-di-tert-butyl-1,4-benzoquinone
    1,6-DCF   1,6-dichlorofructose
    DDT       dichlorodiphenyltrichloroethane
    DEM       diethyl maleate
    DEN       diethylnitrosamine
    DSS       dioctyl sodium sulfosuccinate
    DMBA      7,12-dimethylbenz[a] anthracene
    DMC       dimethylcarbonate
    DMDC      dimethyldicarbonate
    DMH       1,2- dimethyl hydrazine

    EH        epoxide hydrolase
    EOD       7-ethoxycoumarin deethylase

    FAO       Food and Agriculture Organization of the United Nations
    FEMA      Flavor and Extract Manufacturers' Association

    GLDH      glutamate dehydrogenase
    GOT       glutamate-oxalate-transaminase
    GPT       glutamate-pyruvate-transaminase
    GSH       glutathione
    GST       glutathione transferase

    Hb        heamoglobin

    i.m.      intramuscular
    i.p.      intraperitoneal
    IARC      International Agency for Research on Cancer
    IPCS      International Programme on Chemical Safety
    i.v.      intravenous

    JECFA     Joint FAO/WHO Expert Committee on Food Additives

    LD50      lethal dose, median
    LDH       lactate dehydrogenase

    3-MC      3-methyl cholanthrene
    MC        methyl carbamate
    MCH       mean cell haemoglobin
    MCV       mean cell volume
    MEL       minimum effect level
    MFO       mixed function oxidase
    MMU       N-methoxymethyl-o-methyl urethane
    MNNG      methyl-n-nitrosoguanidine
    MP        methylprednisolone
    MRL       maximum residue limit
    MTD       maximum tolerated dose

    NDEA      N-nitrosodiethylamine
    NK        natural killer
    NOAEL     no-observed-adverse-effect level
    NOEL      no-observed-effect level

    ODC       ornithine decarboxylase

    PAPS      3'-phosphoadenosine-5'phosphosulfonate
    PB        phenobarbital
    PBL       peripheral blood lymphocyte
    PEPCK     phosphoenolpyruvate carboxykinase
    p.o.      per os (by mouth)
    ppb       parts per billion
    ppm       parts per million
    PTWI      provisional tolerable weekly intake

    RA        retinyl acetate
    RBC       red blood cell

    sc        subcutaneous(ly)
    SCE       sister chromatid exchange
    SPL       splenic leukocytes

    T3        3,5,3'-triiodothyronine
    rT3       3,3',5'-triiodothyronine
    T4        thyroxine
    TGS       trichlorogalactosucrose
    TPA       12-0-tetradecanoyl phorbol-13-acetate
    TSH       thyrotropin

    UDS       unscheduled DNA synthesis

    WHO       World Health Organization

    See Also:
       Toxicological Abbreviations