ANNEX 2
ABBREVIATIONS USED IN THE MONOGRAPHS
AAF 2-acetylaminofluorene
ADI acceptable daily intake
ALAT alaninc aminotransferase
ALP alkaline phosphatase
ASAT aspartate aminotransferase
ATP adenosine triphosphate
AUC area under the curve
BHA butylated hydroxy anisole
BUN blood urea nitrogen
bw body weight
CHO Chinese hamster ovary
CMC carboxymethyl cellulose
CNS central nervous system
CV conventional flora
DMSO dimethylsulfoxide
DNA deoxyribonucleic acid
ECG electrocardiogram
ED50 effective dose, median
ERG electroretinogram
F female
F1 filial generation, first
F2 filial generation, second
FAO Food and Agriculture Organization of the United
Nations
FDA US Food and Drug Administration
g gram
gamma-GT gamma glutamyl transferase
GC gas chromatography
GF germ-free
GI gastrointestinal
GLP good laboratory practice
GOT glutamate oxalate transaminase
GPT glutmate pyruvate transaminase
GSH glutathione
h hour
H & E hematoxylin and eosin stain
Hb haemoglobin
HDL high density lipoprotein
HPLC high performance liquid chromatography
i.m. intramuscular
i.p. intraperitoneal
i.v. intravenous
IARC International Agency for Research on Cancer
IPCS International Programme on Chemical Safety
JECFA Joint FAO/WHO Expert Committee on Food Additives
kg kilogram
l litre
LD50 lethal dose, median
LDH lactate dehydrogenase
M male
MCH mean corpuscular haemoglobin
MCV mean corpuscular volume
MetHb methaemoglobin
mg milligram
ml millilitre
MS mass spectrometry
MTD maximum tolerated dose
NADPH nicotinamide adenine dinucleotide phosphate
(reduced)
NMR nuclear magnetic resonance
NOAEL no-observed-adverse-effect level
NOEL no-observed-effect level
OCT ornithine carbamyl transferase
PAS para-aminosalicylic acid
p.o. per os (by mouth)
PCV packed cell volume
PT prothrombin time
PTWI provisional tolerable weekly intake
RBC red blood cell count
RNA ribonucleic acid
s.c. subcutaneous
SCE sister chromatid exchange
SEM scanning electron microscopy
SGOT serum glutamate-oxalate transaminase
SGPT serum glutamate-pyruvate transaminase
TSH thyroid-stimulating hormone
UDS unscheduled DNA synthesis
v/v volume per volume
WBC white blood cell
WHO World Health Organization