INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY

    WORLD HEALTH ORGANIZATION



    TOXICOLOGICAL EVALUATION OF SOME
    FOOD COLOURS, EMULSIFIERS, STABILIZERS,
    ANTI-CAKING AGENTS AND CERTAIN
    OTHER SUBSTANCES



    FAO Nutrition Meetings Report Series 
    No. 46A WHO/FOOD ADD/70.36




    The content of this document is the result of the deliberations of the
    Joint FAO/WHO Expert Committee on Food Additives which met in Rome,
    27 May - 4 June 19691





    Food and Agriculture Organization of the United Nations

    World Health Organization



                   
    1 Thirteenth report of the Joint FAO/WHO Expert Committee on Food
    Additives, FAO Nutrition Meetings Report Series, in press;
    Wld Hlth Org. techn.  Rep. Ser., in press.


    CALCIUM AND MAGNESIUM PHOSPHATES TRIBASIC

    Biological Data

    Calcium phosphates insoluble in water and constitute the following
    series: calcium phosphate (monobasic) which is used as acidulant and
    mineral supplement; calcium phosphate (dibasic) is used as dietary
    supplement in doses of 1 g orally; calcium phosphate (tribasic) is
    used as gastric antacid in doses of 1 g orally; and bone phosphate.
    Metabolically they behave as sources of calcium and phosphate ions. 
    These compounds need not be considered separately from other
    monophosphates from the toxicological point of view.

    Magnesium phosphates are mostly insoluble in water and form the
    following series: magnesium phosphate (monobasic); magnesium phosphate
    (dibasic) which is used as laxative, magnesium phosphate (tribasic) is
    used as antacid in doses of 1 g orally. Metabolically they behave as
    sources of magnesium and phosphate ions. These compounds need not be
    considered separately from other monophosphates from the toxicological
    point of view.

    Comment

    Monophosphates have already been evaluated in the Seventh Report of
    the Joint FAO/WHO Expert Committee on Food Additives. The acceptable
    daily intake for man of phosphates as additives should be related to
    the total dietary phosphatesa and calcium intake.

    EVALUATION

    Estimate of acceptable daily intake for man

                                            mg/kg body weight

    Unconditional acceptance                     0 - 30b



                   

    a See Seventh Report of the Joint FAO/WHO Expert Committee on Food
    Additives (1964), Wld Hlth Org. techn. Rep. Ser., 281.

    b As total dietary phosphorous intake from both food and food
    additives.
    

    See Also:
       Toxicological Abbreviations