RECOMMENDATIONS CONCERNING ACCEPTABLE DAILY INTAKES AND RESIDUE LIMITS MADE AT THE 1973 MEETING These recommendations are additional to, or amend, those recorded in Annex 1 of the Report of the 1972 Meeting (FAO/WHO, 1973a) entitled "Index to Documentation and Summary of Recommendations Concerning Acceptable Daily Intakes, Tolerances, Practical Residue Limits, and Guideline Levels as of November 1972". Temporary recommendations are denoted by superscripts a,b,c,d, or e indicating that further work is to be made available not later than 30 June in the year 1974, 1975, 1976 or 1977 respectively. Further exploratory notes are given at the end of this table. ANNEX I Maximum Residue limits acceptable (mg/kg) Pesticides daily and intake Commodity Tolerances Remarks references1 (mg/kg (practical bw) limits Guideline indicated levels2 as (P)) Azinphos-ethyl Tomatoes 1 Residues to be determined as Apples, pears 0.5 azinphos-ethyl and its P = O Vegetables (except potatoes and analogue and expressed as tomatoes) 0.5 azinphos-ethyl Soybeans, (dry) 0.2 Potatoes, cotton-seed, rape seed 0.05* Azinphos-methyl 0.0025 Almond hulls 10 Where azinphos-ethyl also occurs the Peaches 4 total residue should not exceed the 1969b, 1973b Citrus fruit 2 levels recommended for Melons 2 azinphos-methyl except in the case Celery 2 of tomatoes, when the total should not Alfalfa (green), pea vines, soybean exceed 1 mg/kg. vines 2 Tolerances no longer temporary Fruit (except Apricots, citrus fruit, grapes, melons, peaches) 1 Broccoli, Brussels sprouts 1 Vegetables (except broccoli, Brussels sprouts, celery) 0.5 Potatoes 0.2 Almonds (shelled but.) 0.2 Raw cereals, dry soybeans, cotton seed, sunflower seed 0.2 Benomyl Bean vines 30 Residues to be determined as the Cherries, citrus fruit, grapes, sum of benomyl and carbendazim peaches 10 (MBC) and calculated as MBC Maximum Residue limits acceptable (mg/kg) Pesticides daily and intake Commodity Tolerances Remarks references1 (mg/kg (practical bw) limits Guideline indicated levels2 as (P)) Apples, apricots, pears, black berries, blackcurrants, boysenberries, dewberries, loganberries, raspberries, strawberries, tomatoes, sugarbeet tops 5 Nectarines, plums, prunes, beans (lima, snap), beans (dry), celery, mangoes, barley straw, peanut hay 2 Bananas, mushrooms, almond hulls 1 Avocados, Brussels sprouts cucumbers, melons, squash 0.5 Raw cereals, potatoes, sugar beets, almonds, macadamia nuts, peanuts, pecans 0.1* Meat of cattle and sheep, whole milk 0.1* Bromo-propylate 0.008 Apples, bananas, cherries, citrus fruit, grapes, nectarines, peaches, pears, plums, prunes, strawberries, hops (dried), tea (manufactured) 5 Vegetables, cotton-seed 1 Bananas (pulp), citrus fruit (pulp) 0.2 Camphechlor Fat of meat of cattle, goat, pigs Listed as toxaphene in FAO/WHO 1969b and sheep 5 1969b Beans (snap, dry, lima), broccoli, Brussels sprouts, cabbage, carrots, cauliflower, celery, collards, eggplant, kale, kohirabi, Maximum Residue limits acceptable (mg/kg) Pesticides daily and intake Commodity Tolerances Remarks references1 (mg/kg (practical bw) limits Guideline indicated levels2 as (P)) lettuce, okra, onions, parsnips, peas, peppers, pimentoes, pineapples, radishes, rutabegas, spinach, tomatoes, bananas (whole), nuts (shelled) 2 Raw cereals (barley, oat, rice, in husk), rye, sorghum, wheat 2 Maize (grain), peanut (groundnut), rice (polished), soybeans (dry) 0.5 Cotton-seed oil, peanut oil (refined), rapeseed oil (refined), soybean oil (refined) 0.5 Milk and milk products (fat basis) 0.5 Captafol 0.05d Cranberries, leeks 8d Recommendations relate only to the 1970b Apples, pears, eggplants 5d parent compound. Referred to as Pumpkins 2d Difolotan in FAO/WHO 1969a, p. 18 Carrots, onions (bulb), potatoes 0.5d Macadmia nuts (shelled) 0.1d Captan 0.1 Apples, cherries 40 1970b, 1974 Pears 30 Apricots, blueberries, blackcurrants, redcurrants, strawberries 20 Spinach 20 Citrus fruit, peaches, plums 15 Endive, rhubarb, tomatoes 15 Cransberries, raspberries 10 Green beans, cucumbers, lettuce, peppers 10 Raisins 5 Maximum Residue limits acceptable (mg/kg) Pesticides daily and intake Commodity Tolerances Remarks references1 (mg/kg (practical bw) limits Guideline indicated levels2 as (P)) Carbaryl 0.01 Animal feedstuffs (green), alfalfa, 1967b, 1968b, bean and pea vines, clover corn 1969b, 1970b, forage, cowpea foliage, grasses, 1971b peanut hay, sorghum forage, soybean foliage, sugar beet tops 100 Cherries, plums, sorghum grain 10 Cranberries 7 Pears 5 Rice (rough) 3 Root crops (beats, carrots, parsnips, radishes, rutabagas), peanuts (whole) 2 Cowpeas, soybeans (dry) 1 Egg (shell-free) 0.5 Sugarbeets, meat of cattle, goats and sheep 0.2 Carbendazim Cherries, citrus fruit, grapes, 1974b peaches 10 Apples, pears, gooseberries, straw berries, lettuce, tomatoes, sugar beet tops 5 Plums, beans (dwarf), celery, gherkins 2 Bananas (whole), mushrooms 1 Cucumbers, melons, bananas (pulp) 0.5 Raw cereals, sugar beet, coffee beans (raw) 0.1* Maximum Residue limits acceptable (mg/kg) Pesticides daily and intake Commodity Tolerances Remarks references1 (mg/kg (practical bw) limits Guideline indicated levels2 as (P)) Demeton-S-ethyl, 0.005 Currants (black and red), grapes 2 The ADI refers to the sum of the Apples, peaches, plums 1 compounds, demetm-S-methyl, oxy oxydemeton-methyl, Citrus fruit pears, blackberries, demeton-methyl, and demeton-A and gooseberries, raspberries, methyl sulfone. demeton-S-ethyl strawberries, lettuce, summer squash 0.5 The tolerances are to apply to the sulfone Raw cereals 0.2 sum of the three compounds Pears, peas, broccoli, Brussels determined as the sulfers, and sprouts, cabbage, cauliflower, calculated as demeton-S-ethyl cantaloupes, cucumbers, eggplant, pumpkins, watermelons, winter squash, potatoes 0.2 Cotton-seed, sugar beet, turnips 0.1 Meat and fat of cattle, pigs, sheep and poultry; milk and milk products; eggs (shell-free) 0.05* Nuts (shelled) 0.05* Animal feed (green) 5 Animal feed (dry) 10 Dimethoate Strawberries 0.3 From use of formotion and/or 1971b Blackcurrants 2.0 dimethoate Disufoton 0.001c Vegetables, including beans, Residue to be determined as broccoli, Brussels sprouts disulfoton sulfone and cabbage, cauliflower, lettuce, demeton-S-sulfone and expressed as rice (in husk), sugar beet 0.5c disulfoton Cereals (except rice); cotton-seed 0.2c Coffee beans, peanut (kernels), pecans (dry), pineapple 0.1*c Forage crops (green) 5c Maximum Residue limits acceptable (mg/kg) Pesticides daily and intake Commodity Tolerances Remarks references1 (mg/kg (practical bw) limits Guideline indicated levels2 as (P)) Folpet 0.1 Strawberries 20 Recommendations apply only to parent 1970b Lettuce 15 compound. Previous recommendations except for strawberries are confirmed and are no longer temporary Formothion 0.02 Citrus fruit 0.2 The tolerance refers only to the 1970b, 1973b parent compound. The metabolites dimethoate and omethoate arising from the use of formothion are included in the tolerances established for these compounds Hexachloro-benzene See Milk and milk products (fat basis) 0.5 (P) Intake of 0.0006 g/kg daily is remarks Raw cereals 0.05 (P) considerably below any dosage rate 1970b Flour and similar milled cereal known to be harmful (see section products 0.01 (P) Other residue limits recommended in 1969 confirmed Lindane 0.01e Fat of meat of cattle, pigs and Referred to as gamma-BHE prior to 1967b, 1969b sheep 2e 1967. In FAO/WHO 1973a, for fat 1972b Apples, Pears 1e meat etc. 2 mg/kg was Rice (in husk) 0.5e erroneously listed as a practical Milk and milk products (fat basis) 0.1 (p)e residue limit instead of as Sugar beet (roots), sugar beat (tops) 0.2e tolerance Eggs (shell-free) 0.1 (p)e Malathion 0.02 Pulses (dried beans, lentils) 8 1967b, 1968b, 1969b, 1971b Maximum Residue limits acceptable (mg/kg) Pesticides daily and intake Commodity Tolerances Remarks references1 (mg/kg (practical bw) limits Guideline indicated levels2 as (P)) Propoxur 0.02 Animal feedstuffs (green) 5 Recommendations include main Apples, cherries, peaches, pears, metabolites expressed as propoxur plums 3 Blackberries, gooseberries, red-currants, strawberries 3 Vegetables (except potatoes and root vegetables) 3 Potatoes, root vegetables 0.5 Rice grain (rough) 0.5 Rice (hulled) 0.1 Cocoa beans 0.05* Meat 0.05* Milk (whole) 0.05* Quintozene 0.001c Lettuce 3c 1970b Peanuts (kernels) 2c Thiometon 0.005d Apples, cherries (sweet), grapes, Residues are to be determined as 1970b pears, peaches, plum, strawberries, thiometon-sulfone and expressed beans, lettuce, peas, as thiometon peppers, tomatoes, hops (dry) 0.5d Carrots, potatoes, sugarbeet, raw cereals, including maize 0.05* Thiophanate-methyl 0.08 Celery 20b Residues to be determined as Cherries, citrus fruit, grapes, thiophanate-methyl and carbendazim peaches, raspberries 10b (MBC) and expressed as carbendazim Apples, pears, blackcurrants, gooseberries, strawberries, carrots, lettuce, tomatoes, sugarbeet (tops) 5b Maximum Residue limits acceptable (mg/kg) Pesticides daily and intake Commodity Tolerances Remarks references1 (mg/kg (practical bw) limits Guideline indicated levels2 as (P)) Thiophanate-methyl Plums, beans, (broad, dwarf, French runner, kidney), gherkins 2b Bananas (whole), mushrooms 1b Cucumber 0.5b Raw cereals, onions, sugarbeets 0.1*b Tricyclohe-xyltin 0.007e Citrus fruit, tea (manufactured) 2e Expressed as the patent compound hydroxide Meat 0.2 (P)e 1971b Milk and milk products (fat basis) 0.5 (P)e Vemidothion Apples, pears 2 1974 Brussels sprouts 1 Grapes, sugarbeets 0.5 1 References are to FAO/WHO publications (see list of references on p. 26). Date sof publications refer to the first complete or completely revised monograph or to important mentions of the compound in a report. Where a monograph has been completely revised mention is not necessarily made of any earlier ones. Where no date is given, the compound as considered at the 1973 Joint Meeting for the first time. 2 Guideline levels are included to assist administering authorities, even though ADIs have not been established for the individual products, or temporary ADIs established at an earlier date have been withdrawn. The levels recommended are those that need not be exceeded if good practices are followed. * Level at or about the limit of determination. ANNEX II REFERENCES FAO/WHO (1958) Procedures for the testing of intentional food additives to establish their safety for use. Second report of the Joint FAO/WHO Expert Committee on Food Additives. FAO Nutrition Meetings Report Series, No. 17; Wld Hlth Org. techn. Rep. Ser., No. 144 FAO/WHO (1961) Evaluation of the carcinogenic hazards of food additives. Fifth report of the Joint FAO/WHO Expert Committee on Food Additives. FAO Nutrition Meetings Report Series, No. 29; Wld Hlth Org. techn. Rep. Ser., No. 220 FAO/WHO (1964) Evaluation of the toxicity of pesticide residues in food; report of a Joint Meeting of the FAO Committee on Pesticides in Agriculture and the WHO Expert Committee on Pesticide Residues. FAO Meeting Report, No. PL/1963/13; WHO/Food Add/23(1964) FAO/WHO (1965a) Evaluation of the toxicity of pesticide residues in food; report of the Second Joint Meeting of the FAO Committee on Pesticides in Agriculture and the WHO Expert Committee on Pesticide Residues. FAO Meeting Report, No. PL:1965/10; WHO/Food Add/26.65 FAO/WHO (1965b) Evaluation of the toxicity of pesticide residues in food. FAO Meeting Report, No. PL:1965/10/1; WHO/Food Add/27.65 FAO/WHO (1965c) Evaluation of the hazards to consumers resulting from the use of fumigants in the protection of food. FAO Meeting Report, No. PL:1965/10/2; WHO/Food Add/28.65 FAO/WHO (1967a) Pesticide residues in food. Joint report of the FAO Working Party on Pesticide, Residues and the WHO Expert Committee on Pesticide Residues. FAO Agricultural Studies, No. 73; Wld Hlth Org. techn. Rep. Ser., No. 370 FAO/WHO (1967b) Evaluation of some pesticide residues in food. FAO:PL/CP/15; WHO/Food Add/67.32 FAO/WHO (1968a) Pesticide residues. Report of the 1967 Joint Meeting of the FAO Working Party and the WHO Expert Committee. FAO Meeting Report, No. PL:1967/M/11; Wld Hlth Org. techn. Rep. Ser., No. 391 FAO/WHO (1968b) 1967 evaluation of some pesticide residues in food. FAO/PL:1967/M/11/1; WHO/Food Add/68.30 FAO/WHO (1969a) Pesticide residues in food. Report of the 1968, Joint Meeting of the FAO Working Party of Experts on Pesticide Residues and the WHO Expert Committee on Pesticide Residues. FAO Agricultural Studies, No. 78; Wld Hlth Org. techn. Rep. Ser., No. 417 FAO/WHO (1969b) 1969 evaluations of some pesticide residues in food. FAO/PL:1968/M/9/1; WHO/Food Add./69.35 FAO/WHO (1970a) Pesticide residues in food. Report of the 1969 Joint Meeting of the FAO Working Party of Experts on Pesticide Residues and the WHO Expert Group on Pesticide Residues. FAO Agricultural Studies, No. 84; Wld Hlth Org. techn. Rep. Ser., No. 458 FAO/WHO (1970b) 1969 evaluations of some pesticide residues in food. FAO/PL:1969/M/17/1; WHO/Food Add./70.38 FAO/WHO (1971a) Pesticide residues in food. Report of the 1970 Joint Meeting of the FAO Working Party of Experts on Pesticide Residues and the WHO Expert Group on Pesticide Residues. FAO Agricultural Studies, No. 87; Wld Hlth Org. techn. Rep. Ser., No. 474 FAO/WHO (1971b) 1970 evaluations of some pesticide residues in food. AGP:1970/M/12/1; WHO/Food Add./71.42 FAO/WHO (1972a) Pesticide residues in food. Report of the 1971 Joint Meeting of the FAO Working Party of Experts on Pesticide Residues and the WHO Expert Committee on Pesticide Residues. FAO Agricultural Studies, No. 88; Wld Hlth Org. techn. Rep. Ser., No. 502 FAO/WHO (1972b) 1971 evaluations of some pesticide residues in food. AGP-1971/M/9/1; WHO Pesticide Residues Series, No. 1 FAO/WHO (1973a) Pesticide residues in food. Report of the 1972 Joint Meeting of the FAO Working Party of Experts on Pesticide Residues and of the WHO Expert Committee on Pesticide Residues. FAO Agricultural Studies, No. 90; Wld Hlth Org. techn. Rep. Ser., No. 525 FAO/WHO (1973b) 1972 evaluations of some pesticide residues in food. AGP:1972/M/9/1; WHO Pesticide Residues Series, No. 2 FAO/WHO (1974a) Pesticide residues in food. Report of the 1973 Joint Meeting of the FAO Working Party on Pesticide Residues and the WHO Expert Committee on Pesticide Residues. FAO Agricultural Studies No. 92; Wld Hlth Org. techn. Rep. Ser., No. 545 WHO (1967) Procedures for investigating intentional and unintentional food additives. Report of a WHO Scientific Group. Wld Hlth Org. techn. Rep. Ser., No. 348 WHO (1971) Evaluation and testing of drugs for mutagenicity: principles and problems. Report of a WHO Scientific Group. Wld Hlth Org. techn. Rep. Ser., No. 482 WHO (1974) Assessment of mutagenicity and carcinogenicity of chemicals. Report of a WHO Scientific Group. Wld Hlth Org. techn. Rep. Ser., No. 546
See Also: Toxicological Abbreviations