ANNEX 1 ACCEPTABLE DAILY INTAKES, RESIDUE LIMITS AND GUIDELINE LEVELS PROPOSED AT THE 1978 MEETING These figures are additional to, or amend, those recorded in Annex 1 of the reports of earlier meetings, which are summarized in document FAO/WHO 1978c. This Table includes maximum acceptable daily intakes (ADIs), maximum residue limits (MRLs), extraneous residue limits (ERLs) and guideline levels (GLs). These terms are defined in Annex 3 or the Report of the 1975 Meeting (FAO/WHO, 1976a). Some ADIs or MRLs are temporary: in these cases the year in which further data are required is specified in parenthesis. ERLs are identified by the symbol (E) after the limit. Part I lists ADIs, MRLs and ERLs. Part II lists GLs. New, as distinct from amended, recommendations are identified by the symbol (* before the commodity or before the ADI. Residue levels at or about the limit of determination are followed by the symbol *. Certain corrections to previous publications are included. PART I - ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) Pesticide and previous MRL or Guideline evaluations (Refs. are to ADI Commodity ERL level Remarks list of FAO/WHO publications) (mg/kg bw) (mg/kg) (mg/kg) BHC (mixture of isomers) See HCH, technical sec-Butylamine 0.1 Temporary ADI extended at 1976b, 1978b (1981) lower level Captan 0.1 (* Potatoes 0.1 1965b, 1970b, 1974b, 1975b, 1978b Cartap 0.1 Tea (green, dry) 20 ADI and MRL are both 1977b amended Chlordimeform 0.0001 Cottonseed 2 Limits replace all previous 1972b, 1976b, (1979) Cottonseed oil (crude) 2 recommendations. They are 1978b, Cottonseed oil (edible) ) No residues are for the sum of chlordimeform Meat of cattle ) to occur at the and its metabolites PART I - (Cont'd.) Pesticide and previous MRL or Guideline evaluations (Refs. are to ADI Commodity ERL level Remarks list of FAO/WHO publications) (mg/kg bw) (mg/kg) (mg/kg) (* Meat of pigs ) current limit of determined as Meat of poultry ) detection (0.05 4-chloro-o-toluidine and Meat of sheep ) mg/kg). expressed as chlordimeform. Milk ) Milk products ) Chlorothalonil 0.03 (* Cereals (raw) 0.2 (1979) 1975b, 1978b (1979) Coumaphos 0.0005 Milk 0.02(1980) Temporary ADI extended at 1969b, 1973b, (1980) same level. Temporary 1976b MRL for milk has been calculated from previous recommendation of 0.5 mg/kg on fat basis Cyanofenphos 0.005 Temporary ADI extended 1976b (1980) at same level Cyhexatin 0.008 (* Peaches 2 Recommended limits are 1971b, 1974b, (1980) (* Plums 2 now for cyhexatin and its 1975b, 1976b, (* Strawberries 2 organotin metabolites and 1978b (* Beans 0.5 (1980) degradation products, determined Meat 0.2 as total organic Milk 0.05 tin and expressed as Milk products (whole) 0.05 cyhexatin. Limits for meat, milk and milk products were previously ERLs. ERLs for milk and milk products were on a fat basis at the same level. PART I - (Cont'd.) Pesticide and previous MRL or Guideline evaluations (Refs. are to ADI Commodity ERL level Remarks list of FAO/WHO publications) (mg/kg bw) (mg/kg) (mg/kg) DDT 0.005 Carcass meat 5(E) on a fat basis Recommended MRLs and ERLs 1965b, 1967b, (conditional)Fruit 2 replace all previously 1968b, 1969b, Vegetables 2 recommended limits. See 1970b, 1973a, Milk products 1 (E) on a fat basis Section 3.5 of Report. 1978b Eggs 0.5 (E) Cereals(raw) 0.2 (E) Milk 0.05(E) Dialifos Was not considered in 1978. This entry is to correct the erroneous entry of "0.02" for MRL of "Fat of meat of cattle and sheep, milk (fat basis)" in FAO/WHO 1978c. The figure should be 0.2 mg/kg. Dimethoate 0.02 Hops (dried) 3 See Section 3.4 of Report 1965b, 1968b, Apples 2 Limits now refer 1971b, 1974b, Apricots 2 to the sum of dimethoate 1978b Blackcurrants 2 and omethoate (resulting cherries 2 from the use of formo- Citrus fruit 2 thion, dimethoate or Grapes 2 omethoate). MRLs apply Olives 2 also to residues of Peaches 2 (1979) omethoate which has a Pears 2 temporary ADI, and are Plums 2 therefore classed as Vegetables (not temporary MRLs. The otherwise listed) 2 previous MRL for "tree fruit Peppers 1 (incld. citrus") is replaced PART I - (Cont'd.) Pesticide and previous MRL or Guideline evaluations (Refs. are to ADI Commodity ERL level Remarks list of FAO/WHO publications) (mg/kg bw) (mg/kg) (mg/kg) Strawberries 1 by MRLs for the Tomatoes 1 individual crops. Potatoes 0.05 Sugar beet, leaves 1 Sugar beet, roots 0.05 Diquat 0.008 (* Wheat bran 5 MRLs of 0.2 mg/kg previously 1971b, 1973b, Wheat flour (wholemeal) 2 referred to unspecified 1977b, 1978b Wheat flour (white) 0.2 wheat flour and to rice Rice (hulled and/or 0.2 (polished). polished) Ethiofencarb 0.1 Temporary ADI extended at 1978 (1980) same level. Previously recommended limits now refer to the sum of ethiofencarb, its sulphoxide and its sulphone. Fenamiphos 0.0006 Carrots 0.2 All limits are now for 1975b,1978b the sum of fenamiphos, its sulphoxide and its sulphone. Fenthion 0.0005 Temporary ADI extended 1972b, 1976b, (1980) at same level. 1978b Formothion 0.02 Citrus fruit 0.2 The MRLs for formothion on 1970b, 1973b, blackcurrants and strawberries 1974b are withdrawn. PART I - (Cont'd.) Pesticide and previous MRL or Guideline evaluations (Refs. are to ADI Commodity ERL level Remarks list of FAO/WHO publications) (mg/kg bw) (mg/kg) (mg/kg) See Section 3.4 of Report. MRLs recommended for dimethoate also apply to residues resulting from the use of formothion. The ADI was inadvertently omitted from FAO/WHO1978c. Guazatine (*0.03 (* Citrus fruits 5(1980) (* Cereals(raw) 0.1* (* Pineapples 0.1* (* Potatoes 0.1* Sugar cane 0.1* HCH, technical See Section 3.6 of Report. 1969b, 1974b Formerly listed an BHC (mixture of Isomers). The reference 1974b was inadvertently omitted from FAO/WHO 1978c under this heading. Hexachlorobenzene No ADI Previous conditional ADI 1970b, 1974b, withdrawn. See Section 1975b 4.33 of Report. Leptophos No ADI Previous temporary ADI and 1975b, 1976b temporary MRLs withdrawn as leptophos is no longer being manufactured. Previous temporary MRLs listed in FAO/WHO 1978c. PART I - (Cont'd.) Pesticide and previous MRL or Guideline evaluations (Refs. are to ADI Commodity ERL level Remarks list of FAO/WHO publications) (mg/kg bw) (mg/kg) (mg/kg) Lindane 0.01 (* Cocoa butter 1 MRL for milk products replaces 1965b, 1967b, Cocoa mass 1 ERL at same level. 1968b, 1969b, Milk products 0.2 on a fat basis MRL for milk replaces ERL 1970b, 1974b, Milk 0.01 at equivalent level on 1975b, 1976b, fat basis. Limits apply 1978b only to residues arising from use of lindane, not those from HCH technical. Omethoate 0.0005 Temporary ADI extended at 1972b, 1976b (1979) same level. Temporary MRLs for dimethoate apply also to omethoate. See Section 3.4 of Report. Paraquat 0.002 (* Sunflower meal 1971b, 1973b, (animal feed 1977b component) 2 (*Sunflower oil (crude & refined) 0.05* Parathion-methyl 0.001 Temporary ADI extended at 1965b, 1969b, (1980) same level. Temporary MRLs 1973b, 1976b, now refer to the sum of 1978b parathion-methyl and its oxygen analogue. Phosmet (*0.005 (* Blueberries 10 As a temporary ADI has been 1977b, 1978b (1979) (* Kiwifruit 10 allocated, previous GLs are (* Sweet potatoes 10 product washed before replaced by the temporary MR analysis MRLs shown. Limit for whole (* Citrus fruit 5 milk is equivalent to former PART I - (Cont'd.) Pesticide and previous MRL or Guideline evaluations (Refs. are to ADI Commodity ERL level Remarks list of FAO/WHO publications) (mg/kg bw) (mg/kg) (mg/kg) (* Cranberries 5 GL on fat basis. Limits now Forage crops(dry) 5 refer to the sum of phosmet (* Grapes 5 and its oxygen analogue. Apples 1 (* Apricots 1 (1979) (* Nectarines 1 Peaches 1 (* Pears 1 Fat of meat of cattle 1 (* Maize 0.2 kernels and cobs, with husks removed Milk products 0.2 on a fat basis (* Peas(fresh or dried) 0.1 (* Tree nuts 0.1 on shell free basis Potatoes 0.05 Milk 0.01 Pirimicarb 0.01 (* Alfalfa, green 50 dry weight basis Temporary ADI extended 1977b (1980) (* Alfalfa, hay 20 dry weight basis at higher level. (* Barley 0.05* Limits are now for (* Eggs 0.05* shell free (1980) sum of pirimicarb, its (* Meat 0.05* N-formyl-(methylamino) (* Milk 0.05* analogue desmethyl (* Oats 0.05* formamido-pirimicarb) and desmethyl-pirimicarb Propargite 0.08 (* Tea(dry, manufactured) 5 1978b Apples 2 Figs 2 (1981) Pears 2 PART I - (Cont'd.) Pesticide and previous MRL or Guideline evaluations (Refs. are to ADI Commodity ERL level Remarks list of FAO/WHO publications) (mg/kg bw) (mg/kg) (mg/kg) (* Tomatoes 2 (* Cucumbers 0.5 Tecnazene (*0.01 (* Lettuce 2 1975b (1981) (* Potatoes 1 washed before analysis (* Chicory(witloof) 0.2 (1981) (* Tomatoes 0.1 (* Vegetables(except chicory) 0.1 Thiometon Not considered in 1978. This entry is to draw attention to (1) omission of reference 1977b and (2) omission of maize (leaves, stalks, cobs) at 0.1* mg/kg and (3) erroneous listing of fodder beets at 0.1* mg/kg instead of 0.05* mg/kg in 1977a and 1978c Thiophanate-methyl 0.08 See Section 3.3 of Report. 1974b, 1976b, Previously recommended MRLs 1978b now apply to thiophanate-methyl alone. expressed as carbendazim. They previously applied to the sum of thiophanate-methyl and carbendazim, expressed as carbendazim. PART I - (Cont'd.) Pesticide and previous MRL or Guideline evaluations (Refs. are to ADI Commodity ERL level Remarks list of FAO/WHO publications) (mg/kg bw) (mg/kg) (mg/kg) Trichlorfon 0.01 Apples 2 ADI replaces temporary ADI i972b, 1976b Strawberries 1 at same level. Cabbage 0.5 (* Grapes 0.5 (* Meat of sheep 0.1 (* Radishes 0.1 (* Carrots 0.05 (* Eggplants 0.05 (* Parsley 0.05 Triforine (*0.02 (* Peaches 5 MRLs are for residues (* Apples 2 determined as chloral (* Cherries 2 hydrate and expressed as (* Plums 2 triforine. (* Beans 1 (* Blackcurrants 1 (* Blueberries 1 (* Gooseberries 1 (* Red currants 1 (* Strawberries 1 (* Cucurbits 0.5 (* Tomatoes 0.5 (* Brussels sprouts 0.2 (* Cereals(raw) 0.1 (* Tamarillo 0.02 PART II - GUIDELINE LEVELS (GLs) (NO ACCEPTABLE DAILY INTAKES) Pesticide and previous MRL or Guideline evaluations (Refs. are to ADI Commodity ERL level Remarks list of FAO/WHO publications) (mg/kg bw) (mg/kg) (mg/kg) Benomyl No ADI GLs previously recommended 1974b, 1976b for benomyl are replaced by carbendazim. The GLs refer to carbendazim residues, whether occurring as a metabolic product of benomyl or of thiophanate-methyl or from the direct use of carbendazim. See Section 3.3 of the Report. Bioresmethrin No ADI Raw cereals 5 This compound was not 1976b Milled products considered in 1978. This from raw cereals 5 entry is included here Cooked cereal 5 because the Gls recorded in products including 1975, were inadvertently bread 0.05* omitted from FAO/WHO (1978c). Carbendazim No ADI (* Bean vines 30 These Gls replace separate 1974b, 1977b, Cherries 10 Gls for benomyl and carbendazim. 1978b Citrus fruit 10 See Section 3.3 of Peaches 10 Report. No ADI because Apples 5 toxicological data have (* Apricots 5 not been made available. (* Blackberries 5 (* Blackcurrants 5 Boysenberries 5 Carrots 5 (*Dewberries 5 PART II - (Cont'd.) Pesticide and previous MRL or Guideline evaluations (Refs. are to ADI Commodity ERL level Remarks list of FAO/WHO publications) (mg/kg bw) (mg/kg) (mg/kg) Gooseberries 5 Grapes 5 Lettuce 5 (* Loganberries 5 Pears 5 (* Raspberries 5 Strawberries 5 Sugarbeet tops 5 Tomatoes 5 (*Potatoes 3 in the product washed before analysis (*Barley straw 2 Celery 2 (* Dry beans 2 Dwarf beans 2 Gherkins 2 (* Lima beans 2 (* Mangoes 2 (* Nectarines 2 Plums 2 (* Prunes 2 Peanut hay 2 (* Rice straw 2 (* Snap beans 2 Wheat straw 2 (* Almond hulls 1 Bananas 1 in the whole product Mushrooms 1 (* Avocados 0.5 PART II - (Cont'd.) Pesticide and previous MRL or Guideline evaluations (Refs. are to ADI Commodity ERL level Remarks list of FAO/WHO publications) (mg/kg bw) (mg/kg) (mg/kg) Banana 0.5 in the pulp Barley 0.5 (* Brussels sprouts 0.5 Cucumbers 0.5 Melons 0.5 Rice 0.5 Rye 0.5 (* Squash 0.5 Wheat 0.5 Peanut hulls 0.2 (* Almonds 0.1* Coffee beans(raw) 0.1* (* Eggs 0.1* shell-free basis (* Macadamia nuts 0.1* (* Meat of cattle 0.1* (* Meat of poultry 0.1* (* Meat of sheep 0.1* (* Milk 0.1* Peanuts 0.1* (* Pecans 0.1* Sugar beet 0.1* Ethephon No ADI (* Grapes 10 No ADI allocated because toxicological 1978b (* Onions (bulb) 0.5 data were insufficient (* Peaches 0.5 for evaluation.
See Also: Toxicological Abbreviations