PESTICIDE RESIDUES IN FOOD - 1984 Sponsored jointly by FAO and WHO EVALUATIONS 1984 The monographs Data and recommendations of the joint meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Expert Group on Pesticide Residues Rome, 24 September - 3 October 1984 Food and Agriculture Organization of the United Nations Rome 1985 DEMETON-S-METHYL AND RELATED COMPOUNDS (Demeton-S-methyl, Oxydemeton-methyl and Demeton-S-methyl sulphone) Explanation Demeton-S-methyl, oxydemeton-methyl (or demeton-S-methyl sulfoxide) and demeton-S-methyl sulfone were reviewed at several previous meetings (FAO/WHO, 1965b, 1968b, 1969b, 1974b, 1979, 1982 and 1983). An ADI, based primarily on short-term studies, was established in 1965b and was re-affirmed in 1968b. In 1969b, the meeting determined that available toxicological studies had not been performed on a single defined test compound and that materials used in agricultural practice could not be precisely defined. In view of these concerns and the lack of long-term toxicological studies, the ADI was withdrawn in 1969b and additional information, including longterm studies in two species, was required to be submitted. In 1974b, an ADI was re-established on the basis of newly submitted long term studies on rats and dogs and a teratology study on rabbits. A comprehensive and cumulative Monograph on demeton-S-methyl and related compounds was presented in the 1974b report. In 1982, the ADI was again withdrawn because the rat and dog long-term studies and the rabbit teratology study were found to have been conducted in a laboratory where unacceptable laboratory standards and practices had been determined to exist. Although the dog study was validated by Canadian and US-EPA authorities, the rat and rabbit studies were determined to be invalid. A series of toxicological studies on demeton-S-methyl, oxydemeton-methyl and demeton-S-methyl sulfone were presented to the JMPR for consideration in 1983. These studies were not reviewed in 1983. Since then, additional toxicological studies on oxydemeton- methyl have been submitted. All of the studies submitted for evaluation in 1983 and 1984 are reviewed in this Monograph Addendum. It has been convenient to consider the studies on each compound separately.
See Also: Toxicological Abbreviations