ANNEX II ACCEPTABLE DAILY INTAKES AND RESIDUE LIMITS PROPOSED AT THE 1988 MEETING These figures are additional to, or amend, those recorded in Annexes to the reports of earlier meetings. Limits recommended at meetings from 1965 to 1977 inclusive are summarized in document FAO/WHO 1978c. The table includes maximum ADIs (acceptable daily intakes), and proposals for MRLs (maximum residue limits), including one ERL (extraneous residue limit) (for bromide ion). These terms are defined in Annex III of the report of the 1975 meeting. Some ADIs are temporary: this is indicated by the year when toxicological re-evaluation of the compound is scheduled in parenthesis below the ADI. All MRLs for compounds with temporary ADIs are necessarily temporary. MRLs may also be temporary, irrespective of the status of the ADI, because additional information is required for the evaluation of residues. These are followed by the qualification (T). If an MRL is an amendment, the previous value is also recorded, together with the year in which the level was estimated. The absence of a figure in the "Previous" column indicates that the recommendation is the first for the commodity or group concerned. The table includes the Codex Classification Numbers (CCNs) of both the compounds and the commodities listed, to facilitate reference to the Guide to Codex Maximum Limits for Pesticide Residues. CCNs for commodities are those of the revised Classification. Commodities are listed in the order of the "Types" in the Classification, and within each Type in alphabetical order. Different Types are not differentiated by sub-headings, but are separated from one another by spaces. The Types are listed in the following order: Type Code Fruits 01 Vegetables 02 Grasses 03 Nuts and seeds 04 Herbs and spices 05 Mammalian products 06 Poultry products 07 Primary animal feed commoditiesof plant origin 11 Secondary food commodities of plant origin 12 Derived products of plant origin 13 ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) ACEPHATE 0.03 (095) 1976,1979,1981, 1982,1984,1987 Residue: acephate Remarks: ADI increased BENOMYL 0.02 (069) 1973,1975,1978 (report only), 1983 Residue: residues arising from the use of benomyl are covered by the MRLs for carbendazim Remarks: ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) BITERTANOL 0.01 FS 0013 Cherries 2 1 (T) for (144) FS 0014 Plums stone fruits 1983,1984,1986 (including Prunes) 2 (1984) 1987 FP 0009 Pome fruits 1 2 (T) for apple (1984) FS 0012 Stone fruits, 1 1 (T) for except cherries stone fruits and plums (1984) VP 0526 Common bean 0.5 - VC 0424 Cucumber 0.5 - SO 0697 Peanut 0.1* AL 1030 Bean forage (green) 10 dry wt - AL 1270 Peanut forage " 20 dry wt - Residue: bitertanol Remarks: ADI increased. Temporary MRLs recommended by 1984 JMPR for bananas and various cereal grains, forages, straws and fodders are now converted to MRLs. ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) BROMIDE ION 1 ML 0812 Cattle Milk 20 (ERL) - (047) 1968,1969,1971 Residue: bromide ion 1979,1981,1983 CARBENDAZIM 0.01 FB 0018 Berries and other (072) small fruits 5 1/ - 1973,1976,1977, FP 0009 Pome fruits 5 2/ - 1978,1983,1985 1987 VD 0534 Lima bean (dry) W 3/ 2 (1973) GC 0080 Cereal grains 0.5 4/ - Almond hulls W Peanut hulls W 0.2 (1973) ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) CARBENDAZIM SO 0495 Rape seed 0.05* - (cont'd) TN 0085 Tree nuts 0.1* 5/ - Residue: carbendazim Remarks: 1/ Replacing separate recommendations for grapes at 10 mg/kg and various berry fruits at 5 mg/kg. 2/ Replacing separate recommendations for apple and pear at the same level. 3/ Covered by MRL for beans (dry) at the same level. 4/ Replacing separate recommendations for barley, oats, rice, rye and wheat at the same level. 5/ Replacing separate recommendations for chestnuts at 0.2 mg/kg and almonds, macadamia nuts and pecan at 0.1* mg/kg. For a complete list of MRLs for carbendazim, indicating the source(s) of the data on which each limit is based, see monograph on carbendazim in 1988 Evaluations, Part I. ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) DELTAMETHRIN 0.01 ML 0106 Milks 0.01* - (135) 1980,1981,1982, CM 0654 Wheat bran, 1984,1985,1986, unprocessed 5 1/ 2 (1987) 1987 CF 1212 Wheat wholemeal 1 1/ 0.5 (1987) Residue: deltamethrin Remarks: 1/ MRL accommodates post-harvest uses on wheat. DIMETHIPIN 0.02 OC 0691 Cotton seed oil, (151) crude 0.1 - 1985,1987 OR 0691 Cotton seed oil, edible 0.02* - OR 0702 Sunflower seed oil, edible 0.02* - Residue: dimethipin Remarks: TADI replaced by ADI at higher level. TMRLs replaced by MRLs ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) DIMETHOATE 0.01 FT 0305 Olives 1 2 (1967) (027) 1965,1966,1967, GC 0654 Wheat 0.2 - 1970, 1973 (see formothion),1977, OR 0305 Olive oil, refined 0.05 - 1978,1983,1984, DM 0305 Olives, processed 0.05 - 1986,1987 Residue: dimethoate ETHYLENETHIOUREA 0.002 VO 0447 Sweet corn W 0.01* (1974) (108) (1993) (corn-on-the-cob) 1974,1977,1986 1987 GC 0645 Maize W 0.01* (1974) Residue: ethylenethiourea Remarks: TADI extended at same level ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) ETRIMFOS 0.003 FP 0226 Apple 1 0.5 (1982) (123) FS 0240 Apricot 0.05 0.2 (1982) 1980,1982,1986, FS 0247 Peach 0.05 0.1 (1982) 1987 VS 0620 Artichoke, Globe 0.2 0.5 (1982) VB 0402 Brussels sprouts 0.05 0.5 (1982) VB 0404 Cauliflower 0.05 0.2 (1982) VL 0480 Kale 0.5 0.1 (1982) VL 0482 Lettuce, Head 2 (T) 0.5 (1982) VO 0448 Tomato 0.5 0.2 (1982) GC 0640 Barley 5 Po 10 (1980) GC 0645 Maize 5 Po 10 (1980) GC 0654 Wheat 5 Po 10 (1980) CM 0654 Wheat bran, unprocessed 10 PoG 20 (1980) ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) ETRIMFOS CF 1211 Wheat flour 1 PoG 2 (1980) (cont'd) CF 1212 Wheat wholemeal 5 PoG 10 (1980) Residue: sum of etrimfos and its oxygen analogue Remarks: Note changed definition of residue. All decreases in limits are to accommodate the change. Po: MRL covers post-harvest uses. PoG: MRL covers post-harvest uses on the cereal grain. FENITROTHION 0.005 (037) 1969,1974,1976, Residue: fenitrothion 1977,1979,1982, 1983,1984,1986 Remarks: ADI slightly increased. 1987 ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) FENVALERATE 0.02 VB 0402 Brussels sprouts 5 2 (1986) (119) 1979,1981,1982, 1984,1985,1986, 1987 Residue: fenvalerate GLYPHOSATE 0.3 GC 0654 Wheat 5 10 (1987) (158) 1986,1987 CM 0654 Wheat bran, unprocessed 40 50 (1987) CF 1211 Wheat flour 0.5 - CF 1212 Wheat wholemeal 5 - Residue: glyphosate ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) IMAZALIL 0.01 VR 0589 Potato 5 (T) 1/ 5 (1984) 2/ (110) 1977,1980,1984, Residue imazalil 1985,1986 Remarks: 1/ MRL refers to post-harvest use, and applies to seed potatoes washed before analysis. 2/ The limit proposed in 1984 was temporary only because the ADI was temporary at that time. ISOFENFOS 0.001 VA 0385 Onion, Bulb 0.1 - (131) VR 0589 Potato 0.1 - 1981,1982,1984, 1985,1986 Residue: sum of isofenphos and its oxygen analogue Remarks: METHACRIFOS 0.003 (125) (1990) 1980,1982,1986 Residue: methacrifos Remarks: TADI extended at higher level. ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) METHICARB 0.001 VS 0620 Artichoke, Globe 0.05* - (132) TN 0666 Hazelnuts 0.05* - 1981,1983,1984, 1985,1986,1987 Residue: sum of methiocarb, its sulphoxide and its sulphone, expressed as methiocarb Remarks: note changed definition of residue, previously "sum of methiocarb, its sulphoxide and its sulphone." METHOMYL 0.01 PC 0001 Citrus fruits 1 2 (1975) (094) (1989) FP 0009 Pome fruits 2 1/ - 1975,1976,1977 1978,1986,1987 VS 0624 Celery 0.2 3 (1975) VO 0448 Tomato 0.2 1 (1975) AS 0640 Barley straw and fodder, dry 5 10 (1975) ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) METHOMYL AS 0647 Oat straw (cont'd) and fodder, dry 5 10 (1975) AS 0654 Wheat straw and fodder, dry 5 10 (1975) Residue: sum of methomyl and methyl hydroxythioacetimidate ("methomyl oxime"), expressed as methomyl Remarks: 1/ Replacing TMRL for apple at same level METHOPRENE 0.1 GC 0080 Cereal grains 5 Po 10 (1984) (147) 1984,1986,1987 CM 0654 Wheat bran, unprocessed 10 PoG 20 for bran (1984) OR 0645 Maize oil, edible 0.2* - CF 1211 Wheat flour 2 PoG 5 (1984) CF 1212 Wheat wholemeal 5 PoG 10 (1984) Residue: methoprene Remarks: Po: MRL covers post-harvest uses. PoG: MRL covers post-harvest use on the cereal grain. ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) OMETHOATE 0.0003 FT 0305 Olives W 2 (1978) (055) 1971,1975,1978, Residue: omethoate 1979,1981,1984, 1985,1986,1987 Remarks: PACLOBUTRAZOL 0.1 FP 0226 Apple 0.2 - (161) FS 0012 Stone fruits 0.05 - Residue: paclobutrazol Remarks: PERMETHRIN 0.05* VA 0389 Spring onion 0.5 5 (1979) (120) 1979,1980,1981, * Applies to the nominal 40% cis-, 1982,1983,1984, 50% trans- and 25% cis-, 75% trans- 1985,1986,1987 materials only Residue: permethrin (sum of isomers) ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) PHENOTHRIN 0.07 GC 0080 Cereal grains W 5 (1979) (127) for GC 0640 Barley 2 Po 5 for cereal 1979,1980, "d-phenothrin" GC 0651 Sorghum 2 Po grains 1982,1984, GC 0654 Wheat 2 Po (1979) 1987 CM 0649 Rice, husked 0.1 - CM 0654 Wheat bran, unprocessed 5 PoG 15 (1979) CF 1211 Wheat flour 1 PoG - CF 1210 Wheat germ 5 PoG - CF 1212 Wheat wholemeal 2 PoG - Residue: phenothrin (sum of (+)-trans- and (+)-cis-isomers) Remarks: TADI replaced by ADI at higher level. TMRLs replaced by MRLs. Po: MRL covers post-harvest uses. PoG: MRL covers post-harvest use on the cereal grain. ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) PHOSMET 0.02 VO 0447 Sweet corn (103) (corn-on-the-cob) 0.05 0.5 (1986) 1976, 1977 (corr, to 1976), 1978, GC 0645 Maize 0.05 0.5 (1986) 1979,1981,1984, 1985,1986,1987, Residue: sum of phosmet and its oxygen analogue PHOXIM 0.001 VB 0403 Cabbage, Savoy 0.05 * - (141) VA 0385 Onion, Bulb 0.05 * - 1982,1983,1984, 1986,1987 MM 0822 Sheep meat 0.5 (fat) 1 (fat) (1983) Residue: phoxim Remarks: limit for sheep meat covers veterinary uses. THIOMETON 0.003 VL 0469 Chicory leaves 1/ 0.5 0.5 for (076) chicory 1969,1973,1976, (1976) 1979 Residue: sum of thiometon, its sulphoxide and sulphone, expressed as thiometon Remarks: 1/ note changed commodity description ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) THIOPHANATEMETHYL 0.08 All commodities W (077) 1973,1975,1977 Residue: residues arising from the use of thiophanatemethyl 1978 are covered by the MRLs for carbendazim Remarks: TOLYLFLUANID 0.1 FB 0021 Currants, Black, (162) Red, White 5 - FP 0009 Pome fruits 5 - FB 0275 Strawberry 3 - VC 0425 Gherkin 2 - VL 0482 Lettuce, Head 1 - VO 0448 Tomato 2 - Residue: tolylfluanid Remarks: ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs) (cont'd). Pesticide Recommended Recommended MRL (CCN) maximum Commodity (mg/kg) Year(s) of ADI CCN Name New Previous previous (mg/kg bw) (W=withdrawn) evaluation(s) TRIADIMEFON 0.03 FI 0345 Mango 0.1* - (133) 1979,1981,1983, Residue: sum of triadimefon and triadimenol 1984,1985,1986, 1987 Remarks: the PHIs to which existing MRLs for certain cereal grains and straws are related are decreased. Numerical values of MRLs are unchanged. VAMIDOTHION 0.008 (078) Residue: sum of vamidothion, its sulphoxide and sulphone, 1973,1982,1985, expressed as vamidothion 1987 Remarks: TADI replaced by ADI at higher level. THRLs replaced by MRLs VINCLOZOLIN 0.07 (159) 1986,1987 Residue: sum of vinclozolin and all metabolites containing the 3,5-dichloroantline moiety, expressed as vinclozolin. Remarks: TADI replaced by ADI at higher level. TMRLs replaced by MRLs
See Also: Toxicological Abbreviations