VOL.: 30 (1983) (p. 61)
Chem. Abstr. Name: Methanimidamide, N'-(4-chloro-2-methylphenyl)-N,N-dimethyl-
para-Chloro-ortho-toluidine, a metabolite of chlordimeform, was tested for carcinogenicity in two strains of mice and two strains of rats by oral administration in the diet. It was carcinogenic in both strains of mice, producing haemangiosarcomas. The studies in rats were not indicative of a carcinogenic effect, but certain limitations in their design were noted.
Chlordimeform is metabolized to a number of compounds, including para-chloro-ortho-toluidine, which has been identified in the urine of several animal species and of humans.
The available data were inadequate to evaluate the teratogenicity of chlordimeform to experimental animals.
Chlordimeform was negative in tests for DNA damage or mutagenicity in several cellular systems. No data were available, however, with regard to its mutagenicity in mammals, and no overall evaluation of the mutagenicity of chlordimeform could be made.
No data were available to evaluate the teratogenic or chromosomal effects of chlordimeform in humans.
No case report or epidemiological study of the carcinogenicity of chlordimeform alone was available to the Working Group; however, it should be noted that the latent period since introduction of this compound may be too short for a carcinogenic effect to be detected in humans. (See also the section 'Cancer Epidemiology of Pesticide Manufacturers, Formulators and Users', in this volume.)
The available data are insufficient to evaluate the carcinogenicity of chlordimeform to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 59: Group 3)
See Also: Toxicological Abbreviations Chlordimeform (EHC 199, 1998) Chlordimeform (ICSC) Chlordimeform (WHO Pesticide Residues Series 1) Chlordimeform (WHO Pesticide Residues Series 5) Chlordimeform (Pesticide residues in food: 1978 evaluations) Chlordimeform (Pesticide residues in food: 1979 evaluations) Chlordimeform (Pesticide residues in food: 1980 evaluations) Chlordimeform (Pesticide residues in food: 1985 evaluations Part II Toxicology) Chlordimeform (Pesticide residues in food: 1987 evaluations Part II Toxicology)