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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

CHLOROTHALONIL

VOL.: 30 (1983) (p. 319)

CAS No.: 1897-45-6
Chem. Abstr. Name: 1,3-Benzenedicarbonitrile, 2,4,5,6-tetrachloro-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Chlorothalonil was tested for carcinogenicity in mice and rats by administration in the diet; it produced adenomas and adenocarcinomas of the kidney in rats. No evidence of carcinogenicity was found in mice.

No published data were available to evaluate the teratogenicity of this compound to experimental animals.

Chlorothalonil was not mutagenic in two fungal systems and was reported to be nonmutagenic in Salmonella typhimurium. Available data on other systems are inadequate, and no overall evaluation of the mutagenicity of chlorothalonil could be made.

5.2 Human data

Chlorothalonil was introduced commercially in 1969. Its production, formulation and use as a fungicide in agricultural and industrial applications are potential sources of exposure, both of workers and of the general population.

No data were available to evaluate the teratogenic or chromosomal effects of chlorothalonil in humans.

No case report or epidemiological study of the carcinogenicity of chlorothalonil alone was available to the Working Group; however, it should be noted that the period since introduction of this compound may be too short for a carcinogenic effect to be detected in humans. (See also the section 'Cancer Epidemiology of Pesticide Manufacturers, Formulations and Users', in this volume).

5.3 Evaluation

Results of one experiment in rats provide limited evidence that chlorothalonil is carcinogenic to experimental animals. No data on humans were available.

The available data are insufficient to evaluate the carcinogenicity of chlorothalonil to humans.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluations: Suppl. 7 (1987) (p. 60); Vol. 73 (1999)

Synonyms


Last updated: 30 September 1999





















    See Also:
       Toxicological Abbreviations
       Chlorothalonil (EHC 183, 1996)
       Chlorothalonil (HSG 98, 1995)
       Chlorothalonil (ICSC)
       Chlorothalonil (WHO Pesticide Residues Series 4)
       Chlorothalonil (Pesticide residues in food: 1977 evaluations)
       Chlorothalonil (Pesticide residues in food: 1981 evaluations)
       Chlorothalonil (Pesticide residues in food: 1983 evaluations)
       Chlorothalonil (Pesticide residues in food: 1985 evaluations Part II Toxicology)
       Chlorothalonil (Pesticide residues in food: 1987 evaluations Part II Toxicology)
       Chlorothalonil (Pesticide residues in food: 1990 evaluations Toxicology)
       Chlorothalonil (Pesticide residues in food: 1992 evaluations Part II Toxicology)
       Chlorothalonil  (IARC Summary & Evaluation, Volume 73, 1999)