International Agency for Research on Cancer (IARC) - Summaries & Evaluations

For definition of Groups, see Preamble Evaluation.

Supplement 7: (1987) (p. 126)

CAS No.: 98-88-4

A. Evidence for carcinogenicity to humans (inadequate)

Six cases of respiratory cancer were reported among workers in two small factories where benzoyl chloride and its chlorinated precursors were produced [ref: 1].

B. Evidence for carcinogenicity to animals (inadequate)

Benzoyl chloride was tested in two sets of experiments by skin application to female mice. A few skin carcinomas were observed, but their incidence was not statistically significant [ref: 1].

C. Other relevant data

No data were available on the genetic and related effects of benzoyl chloride in humans. It did not induce mutation or DNA damage in bacteria [ref: 2].

Overall evaluation

Benzoyl chloride is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 71 (1999)

Also see previous evaluation: Vol. 29 (1982)

References

1. IARC Monographs, 29, 83-91, 1982

2. IARC Monographs, Suppl. 6, 103-104, 1987

Synonyms

• Benzene carbonyl chloride
• Benzenecarbonyl chloride
• Benzoic acid, chloride
• a-Chlorobenzaldehyde

    See Also:
       Toxicological Abbreviations
       Benzoyl chloride (ICSC)
       Benzoyl Chloride (IARC Summary & Evaluation, Volume 29, 1982)