International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 1 (1972) (p. 80)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Benzidine is carcinogenic in the mouse, rat and hamster, and possibly the dog. Given orally, it has produced bladder carcinoma in the dog after a long latent period and liver tumours in the rat and hamster.

5.2 Human carcinogenicity data

The epidemiological studies showed that occupational exposure to commercial benzidine alone was strongly associated with bladder cancer. In the same studies, exposure to 2-naphthylamine alone was similarly associated with bladder cancer. A number of case reports from several countries support the relationship between this neoplasm and occupational exposure to benzidine.

Subsequent evaluations: Vol. 29 (1982); Suppl. 7 (1987)

Last updated: 12 March 1998

    See Also:
       Toxicological Abbreviations
       Benzidine (ICSC)
       Benzidine  (IARC Summary & Evaluation, Supplement7, 1987)