Amaranth (IARC Summary & Evaluation, Volume 8, 1975)

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

AMARANTH

VOL.: 8 (1975) (p. 41)

CAS No.: 915-67-3
Chem. Abstr. Name: 3-Hydroxy-4-[(4-sulfo-l-naphthalenyl) azo]-2,7-naphthalenedisulfonic acid, trisodium salt

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Amaranth has been tested by the oral route in mice, rats and dogs and by the subcutaneous route in rats. Two oral studies in rats indicating a carcinogenic effect do not allow a definite evaluation: in one study the compound used contained 25-35% of unspecified impurities; in the other, the absence of spontaneous tumours in controls after 33 months is considered to be very unusual.

Other oral studies in mice, rats and dogs gave negative results but were inadequately reported. Subcutaneous experiments in rats could not be evaluated because of the small numbers of animals used or insufficient reporting.

The carcinogenicity of this compound could not be evaluated.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 56: Group 3)

For definition of Groups, see Preamble Evaluation.

Synonyms

Acid Amaranth
Acid Leather Red 12BW
Azo rubine S
Bordeaux S
Calcocid amaranth
C.I. Acid Red 27
C.I. Food Red 9
Dolkwal amaranth
Java amaranth
Naphthol Red B
Victoria Rubine O
Wool red

Last updated: 21 March 1998





























    See Also:
       Toxicological Abbreviations
       Amaranth (WHO Food Additives Series 4)
       Amaranth (WHO Food Additives Series 8)
       Amaranth (WHO Food Additives Series 13)
       Amaranth (WHO Food Additives Series 19)
       AMARANTH (JECFA Evaluation)