VOL.: 16 (1978) (p. 301)
1 Subsequent to the finalization of this evaluation by the Working Group in June 1977, the Secretariat became aware of a paper by Steinhoff (1977), in which a group of 20 male and 20 female Wistar rats received weekly s.c. injections of 100-300 mg/kg bw 4,4'-diaminodiphenyl ether in saline, up to a total dose of 14.4 g/kg bw, during 670 days. A group of 50 control rats received s.c. injections of saline alone for 907 days. Twenty-two (55%) treated rats died with malignant tumours, compared with 13 (26%) in controls. Benign tumours occurred in 22 treated rats and in 10 controls. Ten (25%) treated rats had malignant tumours of the liver (3 multiple), and 12 had benign liver tumours; no such tumours were found in controls.
Subsequent evaluations: Vol 29 (1982); Suppl. 7 (1987) (p. 61: Group 2B)
For definition of Groups, see Preamble Evaluation.
See Also: Toxicological Abbreviations Diaminodiphenyl, 4,4'- Ether (IARC Summary & Evaluation, Volume 29, 1982)