International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 29 (1982) (p. 203)

CAS No.: 101-80-4
Chem. Abstr. Name: Benzenamine, 4,4'-oxybis-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

4,4'-Diaminodiphenyl ether was tested in mice and rats by oral administration and by subcutaneous injection. In two studies in rats, it produced benign and malignant liver-cell tumours following oral or subcutaneous administration; and following its oral administration in one study, benign and malignant follicular-cell tumours of the thyroid were produced. Other studies in rats by oral and subcutaneous administration were not adequate for evaluation. In a study in mice by oral administration it produced benign and malignant liver-cell tumours in females given the high dose and in males given the low dose and adenomas of the Harderian gland in animals of both sexes.

4,4'-Diaminodiphenyl ether is mutagenic to Salmonella typhimurium with metabolic activation.

No data were available to assess its teratogenicity to experimental animals.

5.2 Human data

Occupational exposure to 4,4'-diaminodiphenyl ether probably occurs during its manufacture and its conversion to polyimide-type resins.

No data were available to assess the mutagenicity or teratogenicity of this compound to man.

No case report or epidemiological study was available to the Working Group.

5.3 Evaluation

There is sufficient evidence for the carcinogenicity of 4,4'-diaminodiphenyl ether in mice and rats.

No case report or epidemiological study was available.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 16 (1978)

Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 2B)


Last updated: 9 April 1998

    See Also:
       Toxicological Abbreviations
       Diaminodiphenyl, 4,4'- ether (IARC Summary & Evaluation, Volume 16, 1978)