International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 20 (1979) (p. 179)

CAS No.: 87-68-3
Chem. Abstr. Name: 1,1,2,3,4,4-Hexachloro-1,3-butadiene

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Hexachlorobutadiene was tested in one experiment in rats by oral administration: it produced benign and malignant tumours in the kidneys of animals of both sexes. It was tested inadequately in one experiment in mice by intraperitoneal injection.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group.

The occurrence of hexachlorobutadiene as a by-product in the production of various chlorinated hydrocarbons for over 50 years and its use in some areas as a pesticide indicate that widespread human exposure in both the occupational and general environment occurs. This is confirmed by reports of its occurrence in the environment.

5.3 Evaluation

There is limited evidence that hexachlorobutadiene is carcinogenic in rats.

Subsequent evaluations: Suppl. 7 (1987) (p. 64) Vol. 73 (1999)

For definition of terms, see Preamble Evaluation.


Last updated: 30 September 1999

    See Also:
       Toxicological Abbreviations
       Hexachlorobutadiene (EHC 156, 1994)
       Hexachlorobutadiene (HSG 84, 1993)
       Hexachlorobutadiene (ICSC)
       Hexachlorobutadiene  (IARC Summary & Evaluation, Volume 73, 1999)