International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 27 (1982) (p. 103)

CAS No.: 615-05-4
Chem. Abstr. Name: 1,3-Benzenediamine, 4-methoxy-

2,4-Diaminoanisole sulphate
CAS No.: 39156-41-7 (6219-67-6 for the salt with an unknown ratio of sulphuric acid to diamine)
Chem. Abstr. Name: 1,3-Benzenediamine, 4-methoxy, sulfate (1:1)

5. Summary of Data Reported and Evaluation

5.1 Experimental data

2,4-Diaminoanisole sulphate (technical-grade) was tested by dietary administration in one experiment in mice and in two experiments in one strain of rats. Benign or malignant tumours of the thyroid gland were induced in rats and mice with the highest dose tested; tumours of the skin and of the preputial, clitoral and Zymbal glands were also induced in rats. It was also tested in a hair-dye formulation by skin application in mice and rats, but the studies were considered to be inadequate for evaluation.

2,4-Diaminoanisole or its sulphate was mutagenic for Salmonella typhimurium, cultured mouse lymphoma cells and Drosophila melanogaster. The sulphate produced mitotic recombination in yeast. Neither 2,4-diaminoanisole nor its sulphate induced micronuclei, sperm abnormalities, or dominant lethal mutations in rodents.

5.2 Human data

2,4-Diaminoanisole and its sulphate have been used in hair dyes for over 60 years. In addition to the consumer and occupational exposure resulting from this use, past use of 2,4-diaminoanisole as a chemical intermediate and as a fur-dye component could have resulted in other occupational exposure.

No case report or epidemiological study was available to the Working Group, but see Appendix 1, in this volume.

5.3 Evaluation

There is sufficient evidence for the carcinogenicity of 2,4-diaminoanisole sulphate in experimental animals.

In the absence of epidemiological studies relating specifically to 2,4-diaminoanisole, it should be regarded, for practical purposes, as if it presented a carcinogenic risk to humans.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 16 (1978)

Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 2B); Vol. 79 (2001)

Synonyms for 2,4-Diaminoanisole

Synonyms for 2,4-Diaminoanisole sulphate

Last updated: 8 April 1998

    See Also:
       Toxicological Abbreviations