International Agency for Research on Cancer (IARC) - Summaries & Evaluations
ortho- AND para-ANISIDINE AND THEIR HYDROCHLORIDES
VOL.: 27 (1982) (p. 63)
ortho-Anisidine
CAS No.: 90-04-0
Chem. Abstr. Name: Benzenamine, 2-methoxy-
ortho-Anisidine hydrochloride
CAS No.: 134-29-2
Chem. Abstr. Name: Benzenamine, 2-methoxy-, hydrochloride
para-Anisidine
CAS No.: 104-94-9
Chem. Abstr. Name: Benzenamine, 4-methoxy-
para-Anisidine hydrochloride
CAS No.: 20265-97-8
Chem. Abstr. Name: Benzenamine, 4-methoxy-, hydrochloride
5. Summary of Data Reported and Evaluation
5.1 Experimental data
ortho-Anisidine hydrochloride was tested in mice and rats by dietary
administration. It was carcinogenic in both species, producing
transitional-cell carcinomas of the urinary bladder. para-Anisidine
hydrochloride, tested in the same way, did not produce carcinogenic
effects in mice, and the data in rats were inadequate for evaluation;
there is, in addition, some doubt about the nature of the compound
tested.
While ortho-anisidine hydrochloride was mutagenic for Salmonella
typhimurium, para-anisidine was not. para-Anisidine did not transform
morphologically BHK21 cells in culture.
5.2 Human data
ortho-Anisidine has been produced commercially for over 50 years. Its
use as an intermediate in the manufacture of dyes, pigments and
synthetic guaiacol could result in occupational exposure.
para-Anisidine has been produced commercially since at least 1937.
Its use as a dye intermediate could result in occupational exposure.
No case report or epidemiological study was available to the Working
Group.
5.3 Evaluation
There is sufficient evidence for the carcinogenicity of
ortho-anisidine hydrochloride in experimental animals. In the absence
of data on humans, ortho-anisidine should be regarded, for practical
purposes, as if it presented a carcinogenic risk to humans.
The available data were inadequate to evaluate the carcinogenicity of
para-anisidine hydrochloride in experimental animals. No evaluation
of the carcinogenicity of para-anisidine to humans could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluations: Suppl. 7 (1987) (p. 57: ortho-Anisidine - Group 2B; para-Anisidine - Group 3); Vol. 73 (1999) (ortho-Anisidine)
Synonyms for ortho-Anisidine
- 2-Aminoanisole
- ortho-Aminoanisole
- 1-Amino-2-methoxybenzene
- 2-Anisidine
- ortho-Anisylamine
- 2-Methoxy-1-aminobenzene
- 2-Methoxyaniline
- ortho-Methoxyaniline
- 2-Methoxybenzenamine
- ortho-Methoxyphenylamine
Synonyms for ortho-Anisidine hydrochloride
- 2-Aminoanisole hydrochloride
- ortho-Aminoanisole hydrochloride
- 1-Amino-2-Methylbenzene hydrochloride
- 2-Anisidine hydrochloride
- ortho-Anisylamine hydrochloride
- C.I. 37115
- Fast Red BB Base
- 2-Methoxy-1-aminobenzene hydrochloride
- 2-Methoxy-aniline hydrochloride
- ortho-Methoxyaniline hydrochloride
- 2-Methoxybenzeneamine hydrochloride
- ortho-Methoxyphenylamine hydrochloride
Synonyms for para-Anisidine
- 4-Aminoanisole
- para-Aminoanisole
- 1-Amino-4-methoxybenzene
- 4-Anisidine
- para-Anisylamine
- 4-Methoxy-1-aminobenzene
- 4-Methoxyaniline
- para-Methoxyaniline
- 4-Methoxybenzeneamine
- para-Methoxyphenylamine
Synonyms for para-Anisidine hydrochloride
- 4-Aminoanisole hydrochloride
- para-Aminoanisole hydrochloride
- 1-Amino-4-methoxybenzene hydrochloride
- 4-Anisidine hydrochloride
- para-Anisidine monohydrochloride
- para-Anisylamine hydrochloride
- 4-Methoxy-1-aminobenzene hydrochloride
- 4-Methoxyaniline hydrochloride
- para-Methoxyaniline hydrochloride
- 4-Methoxybenzeneamine hydrochloride
- para-Methoxyphenylamine hydrochloride
Last updated: 30 September 1999