International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 2B)

For definition of Groups, see Preamble Evaluation.

VOL.: 73 (1999) (p. 49)

CAS No.: 90-04-0
Chem. Abstr. Name: 2-Methoxybenzenamine

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Exposure to ortho-anisidine may occur during its production and its use as a chemical intermediate, a corrosion inhibitor and an industrial antioxidant.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

ortho-Anisidine hydrochloride was tested for carcinogenicity in one study in mice and one study in rats by oral administration in the diet. It produced transitional-cell carcinomas of the urinary bladder in animals of each species and sex.

5.4 Other relevant data

Limited information was available to the Working Group on the metabolism of ortho-anisidine. It was shown to be O-dealkylated in rat liver microsomes.

ortho-Anisidine at a high dose increased the incidence of hyperplasia of the bladder in male and female mice.

No data were available on the developmental and reproductive effects of ortho-anisidine.

No data were available on the genetic and related effects of ortho-anisidine in humans. No conclusion can be drawn about its genotoxicity in experimental animals in vivo; however, ortho-anisidine induced gene mutation in bladder cells in an assay in transgenic mice. There is no evidence that it has genotoxic effects in mammalian cells in vitro. ortho-Anisidine was not mutagenic to bacteria.

5.5 Evaluation

There is inadequate evidence in humans for the carcinogenicity of ortho-anisidine.

There is sufficient evidence in experimental animals for the carcinogenicity of ortho-anisidine.

Overall evaluation

ortho-Anisidine is possibly carcinogenic to humans (Group 2B).

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluations: Vol. 27 (1982); Suppl. 7 (1987) (p. 57)


Last updated: 30 September 1999

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       Toxicological Abbreviations