International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p. 327)

CAS No.: 192-65-4
Chem. Abstr. Name: Naphtho(1,2,3,4-def)chrysene

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Dibenzo[a,e]pyrene has been shown to be carcinogenic to experimental animals.

No data on the teratogenicity of this compound were available.

In the one study evaluated, dibenzo[a,e]pyrene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system.

There is inadequate evidence that dibenzo[a,e]pyrene is active in short-term tests.

5.2 Human data

Dibenzo[a,e]pyrene is present as a minor component of the total content of polynuclear aromatic compounds in the environment. Human exposure to dibenzo[a,e]pyrene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated with combustion products.

5.3 Evaluation

There is sufficient evidence that dibenzo[a,e]pyrene is carcinogenic to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 3 (1973)

Subsequent evaluation: Suppl. 7 (1987) (p. 62: Group 2B)


Last updated: 17 April 1998

    See Also:
       Toxicological Abbreviations