ICSC 0826 - AZINPHOS-METHYL

AZINPHOS-METHYL	ICSC: 0826 (March 1998)
Phosphorodithioic acid 0,0-dimethyl S-((4-oxo-11,2,3-benzotriazin-3-(4H)-yl)methyl) ester S-3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-ylmethyl) O,O-dimethyl phosphorodithioate

CAS #: 86-50-0

UN #: 2783

EC Number: 201-676-1

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Use water spray, powder, foam, carbon dioxide.

PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Headache. Pupillary constriction, muscle cramp, excessive salivation. Sweating. Nausea. Dizziness. Wheezing. Laboured breathing. Convulsions. Unconsciousness.	Use ventilation (not if powder), local exhaust or breathing protection.	Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin	MAY BE ABSORBED! See Inhalation.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Eyes	Blurred vision.	Wear face shield or eye protection in combination with breathing protection if powder.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Abdominal cramps. Vomiting. Diarrhoea. Blurred vision. Further see Inhalation.	Do not eat, drink, or smoke during work. Wash hands before eating.	Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Fatal if swallowed, in contact with skin or if inhaled Causes eye irritation May cause an allergic skin reaction Causes damage to central nervous system Causes damage to the central nervous system through prolonged or repeated exposure Very toxic to aquatic life with long lasting effects Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: II
STORAGE
Separated from food and feedstuffs. Well closed.
PACKAGING
Do not transport with food and feedstuffs. Severe marine pollutant.

AZINPHOS-METHYL

ICSC: 0826

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS CRYSTALS. Physical dangers Chemical dangers Decomposes above 200°C . Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides, phosphorus oxides and sulfur oxides.	Formula: C₁₀H₁₂N₃O₃PS₂ Molecular mass: 317.3 Melting point: 73-74°C Density: 1.4 g/cm³ Solubility in water: none Vapour pressure, Pa at 20°C: <0.001 Octanol/water partition coefficient as log Pow: 2.75

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS CRYSTALS.

Physical dangers

Chemical dangers
Decomposes above 200°C . Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides, phosphorus oxides and sulfur oxides.

Formula: C₁₀H₁₂N₃O₃PS₂
Molecular mass: 317.3
Melting point: 73-74°C
Density: 1.4 g/cm³
Solubility in water: none
Vapour pressure, Pa at 20°C: <0.001
Octanol/water partition coefficient as log Pow: 2.75

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. Effects of short-term exposure The substance may cause effects on the nervous system. This may result in convulsions and respiratory failure. Cholinesterase inhibition. Exposure could cause unconsciousness and death. The effects may be delayed. Medical observation is indicated.	Inhalation risk Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered. Effects of long-term or repeated exposure Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Effects of short-term exposure
The substance may cause effects on the nervous system. This may result in convulsions and respiratory failure. Cholinesterase inhibition. Exposure could cause unconsciousness and death. The effects may be delayed. Medical observation is indicated.

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered.

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 2 mg/m³, as TWA; (skin); (SEN); BEI issued. MAK: (inhalable fraction): 1 mg/m³; peak limitation category: II(8); skin absorption (H); sensitization of skin (SH); pregnancy risk group: B

ENVIRONMENT
The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to bees. Avoid release to the environment in circumstances different to normal use.

NOTES
The technical material is a brown waxy solid. Depending on the degree of exposure, periodic medical examination is suggested. The symptoms of acute poisoning do not become manifest until 0.5 to several hours. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Do NOT take working clothes home. Carrier solvents used in commercial formulations may change physical and toxicological properties. If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s).

NOTES

The technical material is a brown waxy solid.
Depending on the degree of exposure, periodic medical examination is suggested.
The symptoms of acute poisoning do not become manifest until 0.5 to several hours.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Do NOT take working clothes home.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s).

ADDITIONAL INFORMATION

EC Classification
Symbol: T+, N; R: 24-26/28-43-50/53; S: (1/2)-28-36/37-45-60-61

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    See Also:
       Toxicological Abbreviations
       Azinphos-Methyl (FAO Meeting Report PL/1965/10/1)
       Azinphos-methyl (FAO/PL:1968/M/9/1)
       Azinphos-methyl (WHO Pesticide Residues Series 2)
       Azinphos-methyl (WHO Pesticide Residues Series 3)
       Azinphos-methyl (WHO Pesticide Residues Series 4)
       Azinphos-methyl (Pesticide residues in food: 1991 evaluations Part II Toxicology)