INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY

    WORLD HEALTH ORGANIZATION



    TOXICOLOGICAL EVALUATION OF SOME
    FOOD COLOURS, EMULSIFIERS, STABILIZERS,
    ANTI-CAKING AGENTS AND CERTAIN
    OTHER SUBSTANCES



    FAO Nutrition Meetings Report Series 
    No. 46A WHO/FOOD ADD/70.36




    The content of this document is the result of the deliberations of the
    Joint FAO/WHO Expert Committee on Food Additives which met in Rome,
    27 May - 4 June 19691





    Food and Agriculture Organization of the United Nations

    World Health Organization



                   
    1 Thirteenth report of the Joint FAO/WHO Expert Committee on Food
    Additives, FAO Nutrition Meetings Report Series, in press;
    Wld Hlth Org. techn.  Rep. Ser., in press.


    HYDROXYPROPYL DISTARCH PHOSPHATE

    Modification is carried out with 0.1 per cent. phosphorus oxychloride
    and 8-10 per cent. of propylene oxide. Cross-linkage would be no
    greater than is experienced on modification with phosphorus
    oxychloride alone and other linkages would probably nol exceed 20 per
    100 anhydroglucose units.

    Biological Data

    Biochemical aspects

    Digestibility was tested in groups of five rats fed for seven days a
    basal diet supplemented by 0, 1 g and 3 g modified or control starch.
    No difference in weight gain was observed (Prier, 1961).

    Acute toxicity

    None available.

    Short-term studies

    None available.

    Long-term studies

    None available.

    Comments

    There are virtually no suitable data available for evaluation.
    Adequate metabolic studies preferably in man are required to elucidate
    the fate of this compound and the moieties containing the various
    modifying radials. Ninety-day studies in two species (one a non-rodent
    mammal) are also required.

    EVALUATION

    Not possible on the data available.

    REFERENCES

    Prier, R. T. (1961) Unpublished report by Wisconsin Alumni Research
    Foundation No. 1031347/8, submitted by Stein, Hall & C.. Inc.
    

    See Also:
       Toxicological Abbreviations
       Hydroxypropyl distarch phosphate (WHO Food Additives Series 1)
       Hydroxypropyl distarch phosphate (WHO Food Additives Series 5)
       Hydroxypropyl distarch phosphate (WHO Food Additives Series 6)
       HYDROXYPROPYL DISTARCH PHOSPHATE (JECFA Evaluation)