FAO/PL:1967/M/11/1
    WHO/Food Add./68.30

    1967 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD

    THE MONOGRAPHS

    The content of this document is the result of the deliberations of the
    Joint Meeting of the FAO Working Party of Experts and the WHO Expert
    Committee on Pesticide Residues, which met in Rome, 4 - 11 December,
    1967. (FAO/WHO, 1968)

    FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS
    WORLD HEALTH ORGANIZATION
    Rome, 1968

    DIPHENYL

    This pesticide was evaluated by the 1966 Joint Meeting of the FAO
    Working Party and the WHO Expert Committee on Pesticide Residues
    (FAO/WHO, 1967). No additional data were considered on this compound
    in 1967 but the "Comments" and "TOXICOLOGICAL EVALUATION" have been
    slightly amended to read as follows:

    Comments

    Diphenyl appears to have been studied mostly in dogs and rats, and
    special aspects have been investigated in other species. Long-term
    studies have been carried out only in rats. The suspicion of
    carcinogenicity raised by a study carried out under inadequate
    conditions was not confirmed in later reports. In vivo and in
    vitro studies in several species including man, reveal a common
    detoxification mechanism. Information on possible chemical changes
    undergone by diphenyl on the fruit is desired.

    Specifications are now available on request.

    TOXICOLOGICAL EVALUATION

    Level causing no toxicological effect

    Rat : 500 ppm in the diet, equivalent to 25 mg/kg/day

    Dog : 25 mg/kg/day

    Monkey : 50 mg/kg/day 

    Estimate of acceptable daily intake for man

    Since children and ill people may consume a large amount of citrus
    fruit, a higher safety factor than usual has been used.

    0-0.125 mg/kg body weight.

    REFERENCES PERTINENT TO EVALUATION FOR ACCEPTABLE DAILY INTAKE

    FAO/WHO. (1967) FAO, PL: CP/15; WHO/Food Add./67.32
    

    See Also:
       Toxicological Abbreviations
       Diphenyl (FAO Nutrition Meetings Report Series 38a)
       DIPHENYL (JECFA Evaluation)
       Diphenyl (FAO/PL:CP/15)