PESTICIDE RESIDUES IN FOOD - 1982


    Sponsored jointly by FAO and WHO






    EVALUATIONS 1982





    Data and recommendations of the joint meeting
    of the FAO Panel of Experts on Pesticide Residues
    in Food and the Environment and the
    WHO Expert Group on Pesticide Residues
    Rome, 23 November - 2 December 1982

    Food and Agriculture Organization of the United Nations
    Rome 1983


    FENITROTHION

    

    Explanation

         The Joint Meeting evaluated fenitrothion in 1969, 1974, 1976,
    1977 and 1979 (FAO/WHO 1970, 1975, 1977 and 1978, 1980). 1 An ADI was
    partly supported by studies conducted by Industrial Bio-Test
    Laboratories (IBT), for which no replacement studies, independently
    obtained validations or additional data have been submitted to the
    JMPR. Accordingly, the ADI for fenitrothion was re-evaluated.

    EVALUATION FOR ACCEPTABLE DAILY INTAKE

    COMMENTS

         The non-rodent mammalian toxicity studies (Burtner  et al 1974;
    Lindberg  et al 1972; Mastalski 1971 a,b,c) the rabbit teratology
    study (Ladd 1971), and the 21-day study using human volunteers
    (Garofolo  et al 1972) were all performed by IBT and were used as the
    basis for the ADI. No independently obtained validations, replacement
    studies or other additional data have been submitted to the JMPR
    concerning these data. Considering the absence of adequate data on
    non-rodent mammalian species, including humans, as well as the need
    for an adequate teratology study, the present ADI is retained as a
    temporary ADI, using a slightly increased safety factor, pending
    receipt of data validations and/or additional data.

              

    1  See Annex 2 for WHO and FAO documentation.

    TOXICOLOGICAL EVALUATION

    Level Causing no Toxicological Effect

    Rat : 5 ppm in the diet, equivalent to 0.25 mg/kg bw.

    Estimate of Temporary Acceptable Daily Intake for Man

    0 - 0.001 mg/kg bw.

    FURTHER WORK OR INFORMATION

    Required (by 1984)

    1.   A 12-month toxicity study in the dog.

    2.   A teratology study in a suitable species.

    3.   Further observations in humans.

    REFERENCES

    Burtner, B.R., Kennedy, G.L. and Keplinger, M.L. 90-day subacute oral
    1974      study. One-year chronic oral cholinesterase activity study,
              and two-year chronic oral toxicity study with Sumithion
              technical in beagle dogs. Report from Industrial Bio-Test
              Laboratories, Inc., submitted to the World Health
              Organization by Sumitomo Chemical Co. Ltd. (Unpublished)

    Garofolo, M., Palazzolo, R.J. and Sanders, R.G. A study on the effects
    1972      of sumithon on plasma and erythrocyte cholinesterase
              activity in human subjects during subacute oral
              administration. Report from Industrial Bio-Test
              Laboratories, submitted to the World Health Organization by
              Sumitomo Chemical Co. Ltd. (Unpublished)

    Ladd, R. Teratogenic study with sumithion(R) technical in albino
    1971      rabbits. Report from Industrial Bio-Test Laboratories
              submitted to the World Health Organization by Sumitomo
              Chemical Co. Ltd. (Unpublished)

    Lindberg, D.C., Wright, P.L. and Keplinger, M.L. 90-day subacute oral
    1972      toxicity study with sumithion technical in beagle dogs.
              Report submitted to the World Health Organization by
              Sumitomo Chemical Co. Ltd. (Unpublished)

    Mastalski, K. Acute oral toxicity study with Sumioxon pure in beagle
    1971a     dogs. Report from Industrial Bio-Test Laboratories,
              submitted to the World Health Organization by Sumitomo
              Chemical Co. Ltd. (Unpublished)

    1971b Acute oral toxicity study with p-nitro metacresol in beagle
              dogs. Report from Industrial Bio-Test Laboratories submitted
              to the World Health Organization by Sumitomo Chemical Co.
              Ltd. (Unpublished)

    1971c Acute oral toxicity study with sumithion technical grade in
              beagle dogs. Report from Industrial Bio-Test Laboratories
              submitted to the World Health Organization by Sumitomo
              Chemical Co. Ltd. (Unpublished)

    See Also:
       Toxicological Abbreviations
       Fenitrothion (EHC 133, 1992)
       Fenitrothion (HSG 65, 1991)
       Fenitrothion (ICSC)
       Fenitrothion (FAO/PL:1969/M/17/1)
       Fenitrothion (WHO Pesticide Residues Series 4)
       Fenitrothion (Pesticide residues in food: 1976 evaluations)
       Fenitrothion (Pesticide residues in food: 1977 evaluations)
       Fenitrothion (Pesticide residues in food: 1979 evaluations)
       Fenitrothion (Pesticide residues in food: 1983 evaluations)
       Fenitrothion (Pesticide residues in food: 1984 evaluations)
       Fenitrothion (Pesticide residues in food: 1986 evaluations Part II Toxicology)
       Fenitrothion (Pesticide residues in food: 1988 evaluations Part II Toxicology)
       Fenitrothion (JMPR Evaluations 2000 Part II Toxicological)