PESTICIDE RESIDUES IN FOOD - 1982 Sponsored jointly by FAO and WHO EVALUATIONS 1982 Data and recommendations of the joint meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Expert Group on Pesticide Residues Rome, 23 November - 2 December 1982 Food and Agriculture Organization of the United Nations Rome 1983 PARAQUATExplanation Paraquat was evaluated by the Joint Meeting of 1970, 1972 and 1976 (FAO/WHO 1971b, 1973b and 1976).1 An ADI was established (FAO/WHO 1973b) on the basis of long-term studies conducted by Industrial Bio-Test Laboratories (IBT), for which no replacement studies, validations or additional data have been submitted to the JMPR. Accordingly, the ADI for paraquat was re-evaluated. EVALUATION FOR ACCEPTABLE DAILY INTAKE COMMENTS A substantial amount of the toxicological data serving as the basis for the ADI for paraquat are essentially IBT in origin (Baran and Calanoba 1965; Cervenka et al 1964; Kohn et al 1964; Palazzolo et al 1964 and 1965). Several replacement studies are in progress. The data developed by Fletcher et al (1972a, b) and McElligott (1966) provide information on the reproductive/teratogenic response in rats/rabbits, respectively, and on the oncogenic response in mice. No independently obtained validations, replacement studies or other additional data have been submitted to the JMPR concerning these data. Considering the evidence available, which demonstrates that paraquat accumulates in the lung following ingestion, resulting in rapid progressive fibrosis of the lung, and that renal failure may also occur, as evidenced by kidney hydropic degeneration, it is recommended that the present ADI be retained as a temporary ADI, pending receipt of data validation and/or additional data. 1 See Annex 2 for WHO and FAO documentation. TOXICOLOGICAL EVALUATION Level Causing no Toxicological Effect Rat : 30 ppm in the diet, equivalent to 1.5 mg/kg bw. Estimate of Temporary Acceptable Daily Intake for Man 0 - 0.001 mg/kg bw as paraquat dichloride (0-0.0007 mg/kg bw expressed as paraquat ion). FURTHER WORK OR INFORMATION Required (by 1985) 1. A chronic toxicity/carcinogenicity study in the rat. 2. A 12-month oral study in the dog. 3. A multigeneration study in the rat. Desirable 1. Further observations in humans. REFERENCES Baran, J. and Calandra, J.C. Two-year chronic oral toxicity of 1965 paraquat-beagle dogs. Report from Industrial Bio-Test Laboratories (August 1964) submitted to the World Health Organization from ICI through Chevron Chemical Co. (Unpublished) Cervenka, H., Kay, J.H. and Calandra, J.C. Chronic oral toxicity of 1964 paraquat-beagle dogs. Report from Industrial Bio-Test Laboratories (August 1964) submitted to the World Health Organization from ICI through Chevron Chemical Co. (Unpublished) Fletcher, K., Herring, C.M. and Robinson, V.M. Paraquat three 1972a generation reproduction study in rats. Report from ICI Industrial Hygiene Research Laboratories, submitted to the World Health Organization from ICI Industrial Hygiene Research Laboratories. (Unpublished) Fletcher, K., Flegg, R. and Kinch, D.A. Paraquat: carcinogenic study 1972b in the mouse. Report from ICI Industrial Hygiene Research Laboratories, submitted to the World Health Organization from ICI, Industrial Hygiene Research Laboratories. (Unpublished) Kohn, F.E., Kay, J.H. and Calandra, J.C. Two-year chronic oral 1964 toxicity of paraquat-albino rats. Report from Industrial Bio-Test Laboratories (July 1964) submitted to the World Health Organization from ICI through Chevron Chemical Co. (Unpublished) Palazzolo, R.J., Kay, J.H. and Calandra, J.C. Acute aerosol inhalation 1964 toxicity of paraquat dichloride. Report from Industrial Bio-Test Laboratories Inc. submitted to the World Health Organization from ICI (15 April 1964) through Chevron Chemical Co. (Unpublished) 1965 Sub-acute aerosol inhalation toxicity of paraquat dichloride. Report from Industrial Bio-Test Laboratories (January 1965) submitted to the World Health Organization from ICI Ltd. through Chevron Chemical Co. (Unpublished) McElligott, T.F. Reproduction in paraquat-treated rabbits. Report from 1966 ICI Industrial Hygiene Research Laboratories, submitted to the World Health Organization from ICI Industrial Hygiene Research Laboratories. (Unpublished)
See Also: Toxicological Abbreviations Paraquat (HSG 51, 1991) Paraquat (PIM 399) Paraquat (JMPR Evaluations 2003 Part II Toxicological) Paraquat (AGP:1970/M/12/1) Paraquat (WHO Pesticide Residues Series 2) Paraquat (Pesticide residues in food: 1976 evaluations) Paraquat (Pesticide residues in food: 1978 evaluations) Paraquat (Pesticide residues in food: 1981 evaluations) Paraquat (Pesticide residues in food: 1986 evaluations Part II Toxicology)