International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 3)

VOL.: 5 (1974) (p. 193)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Methoxychlor was tested by the oral route only in the rat. Three experiments, including one employing dietary levels of up to 1600 ppm (equivalent to about 80 mg/kg bw/day), provided no evidence of carcinogenicity. Because of inadequate reporting, conclusions cannot be drawn from the results of a fourth experiment in which some liver tumours were observed in rats fed up to 2000 ppm in the diet (equivalent to about 100 mg/kg bw/day). Data from these four experiments do not allow an evaluation of the carcinogenicity of methoxychlor to be made at the present time.

No tumours were reported in limited skin application and subcutaneous injection (single-dose) studies.

5.2 Human carcinogenicity data

No epidemiological studies were available to the Working Group.

Subsequent evaluation: Vol. 20 (1979); Suppl. 7 (1987) (p. 66: Group 3)

For definition of Groups, see Preamble Evaluation.

Last updated: 17 March 1998

    See Also:
       Toxicological Abbreviations
       Methoxychlor (ICSC)
       Methoxychlor (FAO Meeting Report PL/1965/10/1)
       Methoxychlor (Pesticide residues in food: 1977 evaluations)
       Methoxychlor (IARC Summary & Evaluation, Volume 20, 1979)