VOL.: 20 (1979) (p. 259)
Chem. Abstr. Name: 1,1'-(2,2,2-Trichloroethylidene)bis(4-methoxybenzene)
Methoxychlor was not mutagenic in bacteria, yeast or Drosophila melanogaster. Cytogenic and dominant lethal tests in mice were also negative.
Methoxychlor is foetotoxic.
N.B. - Subsequent to the meeting of the Working Group, the Secretariat became aware of a paper by Reuber (1979a), reporting the results of a study carried out in 1969 in which oral administration of methoxychlor induced testicular carcinomas in 27/51 male Balb/c mice, compared with 8/71 controls, but in none of the C3H mice tested. A further paper by Reuber (1979b) reported the results of a study carried out in 1951 in which oral administration of methoxychlor to Osborne-Mendel rats induced liver carcinomas.
The extensive production and the widespread use of methoxychlor over the past several decades, together with the persistent nature of the compound, indicate that widespread human exposure occurs. This is confirmed by many reports of its occurrence in the general environment and by its presence in human blood.
Previous evaluation: Vol. 5 (1974)
Subsequent evaluation: Suppl. 7 (1987) (p. 66: Group 3)
For definition of groups, see Preamble Evaluation.
See Also: Toxicological Abbreviations Methoxychlor (ICSC) Methoxychlor (FAO Meeting Report PL/1965/10/1) Methoxychlor (Pesticide residues in food: 1977 evaluations) Methoxychlor (IARC Summary & Evaluation, Volume 5, 1974)