International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 7 (1974) (p. 31)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Amitrole induced thyroid and liver tumours in both mice and rats following oral and/or subcutaneous administration. An increased incidence of liver-cell tumours in the trout has also been reported following oral administration, but this cannot be considered as conclusive until additional studies using properly controlled diets are reported. Limited skin-painting studies in mice gave no evidence of skin carcinogenicity.

5.2 Human carcinogenicity data

A single, small, cohort study raises the suspicion that amitrole may be carcinogenic to man, but the findings cannot be regarded as conclusive.

Subsequent evaluations: Vol. 41 (1986); Suppl. 7 (1987); Vol. 79 (2001)

Last updated: 20 March 1998

    See Also:
       Toxicological Abbreviations
       Amitrole (EHC 158, 1994)
       Amitrole (HSG 85, 1994)
       Amitrole (ICSC)
       Amitrole (WHO Pesticide Residues Series 4)
       Amitrole (Pesticide residues in food: 1977 evaluations)
       Amitrole (Pesticide residues in food: 1993 evaluations Part II Toxicology)
       Amitrole (Pesticide residues in food: 1997 evaluations Part II Toxicological & Environmental)
       Amitrole  (IARC Summary & Evaluation, Supplement7, 1987)
       Amitrole  (IARC Summary & Evaluation, Volume 41, 1986)
       Amitrole  (IARC Summary & Evaluation, Volume 79, 2001)