International Agency for Research on Cancer (IARC) - Summaries & Evaluations

(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 53 (1991) (p. 93)

CAS No.: 116-06-3
Chem. Abstr. Name: 2-Methyl-2-(methylthio)propanal, O-[(methylamino)carbonyl]oxime

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Aldicarb is a moderately persistent systemic insecticide, acaricide and nematicide formulated as granules. It was first used in 1970 and is applied mainly on cotton and potatoes.

Exposure to aldicarb may occur during its production and application and, at lower levels, via contamination of groundwater and consumption of food containing residues.

5.2 Carcinogenicity in humans

No data were available to the Working Group.

5.3 Carcinogenicity in experimental animals

Aldicarb has not been tested adequately for carcinogenicity in experimental animals.

5.4 Other relevant data

Aldicarb is highly acutely toxic: it is one of the most potent cholinesterase-inhibiting carbamate insecticides.

No data were available on the genetic and related effects of aldicarb in humans.

Aldicarb induced chromosomal aberrations in rat bone-marrow cells in vivo. It induced various kinds of chromosomal damage and gene mutation in cultured human cells and induced gene mutation in rodent cells. It did not cause mutation in bacteria.

5.5 Evaluation

No data were available from studies in humans.

There is inadequate evidence for the carcinogenicity of aldicarb in experimental animals.

Overall evaluation

Aldicarb is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.


Last updated: 20 November 1997

    See Also:
       Toxicological Abbreviations
       Aldicarb (EHC 121, 1991)
       Aldicarb (HSG 64, 1991)
       Aldicarb (ICSC)
       Aldicarb (Pesticide residues in food: 1979 evaluations)
       Aldicarb (Pesticide residues in food: 1982 evaluations)
       Aldicarb (Pesticide residues in food: 1992 evaluations Part II Toxicology)