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MALATHIONICSC: 0172
Diethyl(dimethoxythiophosphorylthio)succinate
S-1,2-bis(Ethoxycarbonyl)ethyl O,O-dimethylphosphorodithioate
Butanedioic acid, {(dimethoxyphosphinothioyl)thio}-, diethyl ester
Diethyl 2-dimethoxyphosphinothioylsulfanylbutanedioate
November 2019
CAS #: 121-75-5
UN #: 3082
EC Number: 204-497-7

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  Risk of fire and explosion if formulations contain flammable/explosive solvents.  NO open flames.    Use foam, powder, carbon dioxide.   

 AVOID ALL CONTACT! FIRST AID: USE PERSONAL PROTECTION. 
  SYMPTOMS PREVENTION FIRST AID
Inhalation Muscle twitching. Pupillary constriction, muscle cramp, excessive salivation. Sweating. Nausea. Dizziness. Convulsions. Unconsciousness. Laboured breathing.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Refer immediately for medical attention. See Notes. 
Skin MAY BE ABSORBED! Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention. See Notes. 
Eyes   Wear safety goggles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal cramps. Diarrhoea. Vomiting. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Refer immediately for medical attention. See Notes. 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. See Chemical Dangers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

excl mark;warncancer;health hazenviro;aqua
DANGER
Harmful if swallowed
May cause cancer
Very toxic to aquatic life with long lasting effects 

Transportation
UN Classification
UN Hazard Class: 9; UN Pack Group: III 

STORAGE
Store only in original packaging. Separated from strong oxidants and food and feedstuffs. Keep in a well-ventilated room. Store in an area without drain or sewer access. 
PACKAGING
Do not transport with food and feedstuffs.
Marine pollutant. 
MALATHION ICSC: 0172
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
YELLOW-TO-BROWN LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including phosphorus oxides and sulfur oxides. Reacts violently with strong oxidants. This generates fire and explosion hazard. Attacks iron, some other metals, some forms of plastic and rubber. 

Formula: C10H19O6PS2
Molecular mass: 330.4
Melting point: 3°C
Relative density (water = 1): 1.2
Solubility in water, mg/l: 143 (very slightly soluble)
Vapour pressure at 30°C: negligible
Relative vapour density (air = 1): 11.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 163°C c.c.
Octanol/water partition coefficient as log Pow: 2.89  


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Effects of short-term exposure
The substance may cause effects on the central nervous system. Cholinesterase inhibition. This may result in convulsions and respiratory depression. The effects may be delayed. Medical observation is indicated. 

Inhalation risk
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. This substance is probably carcinogenic to humans. 


OCCUPATIONAL EXPOSURE LIMITS
TLV: 1 mg/m3, as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued.
MAK: (inhalable fraction): 15 mg/m3; peak limitation category: II(4); pregnancy risk group: D 

ENVIRONMENT
The substance is very toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment. This substance may be hazardous to the environment. Special attention should be given to bees. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s).
Carrier solvents used in commercial formulations may change physical and toxicological properties. 

ADDITIONAL INFORMATION
  EC Classification
 

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    See Also:
       Toxicological Abbreviations
       Malathion (FAO Meeting Report PL/1965/10/1)
       Malathion (FAO/PL:CP/15)
       Malathion (FAO/PL:1967/M/11/1)
       Malathion (JMPR Evaluations 2003 Part II Toxicological)
       Malathion (FAO/PL:1968/M/9/1)
       Malathion (FAO/PL:1969/M/17/1)
       Malathion (AGP:1970/M/12/1)
       Malathion (WHO Pesticide Residues Series 3)
       Malathion (WHO Pesticide Residues Series 5)
       Malathion (Pesticide residues in food: 1977 evaluations)
       Malathion (Pesticide residues in food: 1984 evaluations)
       Malathion (Pesticide residues in food: 1997 evaluations Part II Toxicological & Environmental)
       Malathion (IARC Summary & Evaluation, Volume 30, 1983)