PESTICIDE RESIDUES IN FOOD - 1979 Sponsored jointly by FAO and WHO EVALUATIONS 1979 Joint meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Expert Group on Pesticide Residues Geneva, 3-12 December 1979 THIABENDAZOLE Explanation At the 11th Session of the CCPR the view was expressed that the proposed MRL of 0.1 mg/kg for strawberries was too low. Residue data from the use of thiabendazole on strawberries as well as for tomatoes, cucumbers and cherries were received from Denmark. They are assessed in this addendum. USE PATTERN Preharvest Rate, kg/ha (Denmark) Commodity or Formulation percent Strawberry 0.6 40% Emul. Tomato* 0.10% 40% Emul. (2 g/plant) Cherries 0.8 40% Emul. Cucumber* 0.10% 40% Emul. (* Glasshouse use) RESIDUES RESULTING FROM SUPERVISED TRIALS Data received from Denmark are summarized in Table 1 (Voldum-Claussen, 1979). Strawberries The 0.1 MRL for thiabendazole on strawberries was based on a fumigant treatment in greenhouses and a 3-4 day preharvest interval. Treatment with 24 g thiabendazole per 100 m2. Under these conditions the limited data indicated that an MRL of 0.1 mg/kg would not be exceeded. In Denmark no pre-harvest interval is required. The data indicate that the outdoor spray treatment results in residues around 0.7 mg/kg at 1 day and that these residues do not dissipate significantly within 7 days. Tomato The 0.1 mg/kg MRL for tomatoes was also based on greenhouse fumigation in the Netherlands although the rate was 12-18 g/100 m2. The Denmark application is also an indoor treatment, but is with a spray treatment with a 0.10% emulsifiable formulation. Again, the residue data in Table 1 indicate a residue of around 0.7 mg/kg at 1 day and again there is little dissipation within 7 days. The residue at 1-7 days is around 2 mg/kg from three applications. Table 1. Residues from trials with Thiabendazole in Denmark (1979) Applications of Crop 40% Emulsion Residues in mg/kg at intervals after applicationa No. rate kg ai/ha 4 hrs 1 day 2 days 4 days 7 days Strawberry 1 0.6 0.68 0.76 0.74 0.60 (0.67-0.70) (0.75-0.78) (0.62-0.86) (0.52-0.69) Tomatob 1 0.10% 0.64 0.70 0.71 0.54 (0.2 g/plant) (0.58-0.69) (0.69-0.70) (0.58-0.85) (0.51-0.56) 3 0.10% 1.9 2.0 2.1 1.5 (0.2 g/plant) (1.6-2.3) (1.9-2.1) (1.7-2.4) (1.4-1.7) Cherries 1 0.8 5.3 3.6 (4.7-5.8) (2.9-4.2) Cucumberb 1 0.10% 0.97 0.80 0.71 0.32 (0.80-1.1) (0.55-1.0) (0.47-0.96) (0.30-0.35) a. Limit of determination 0.1 mg/kg b. Glasshouse use Cherries No MRL has been proposed for cherries. The data supplied by Denmark show residues near 6 mg/kg at four hours after the spray treatment which dissipates to only around 4 mg/kg at seven days. Cucumber No MRL has been proposed for thiabendazole on cucumbers. The data in Table 1 show initial residues of 1 mg/kg one day after a spray application indoors. Again the residue is slow to dissipate. FATE OF RESIDUES IN FOOD IN COMMERCE OR AT CONSUMPTION No additional information was received. METHODS OF RESIDUE ANALYSIS No new methods of analysis were received. The analyses of Table 1 were based on extraction with ethyl acetate in alkaline solution, clean-up by liquid-liquid partitioning and determination by spectrometry. Limit of determination was 0.10 mg/kg. APPRAISAL Residue data on strawberries were received from Denmark to support the view that the current 0.1 mg/kg MRL is too low. Data from trials with tomatoes, cherries and cucumbers were also received. The data indicate that the current 0.1 mg/kg MRLs on strawberries and tomatoes which were based oil greenhouse fumigation in the Netherlands, are too low for the practices in Denmark where spray treatments with all emulsifiable formulation is used. There are currently no MRLs for thiabendazole on cherries and cucumbers and available data do not warrant their proposal at this time. RECOMMENDATIONS It is recommended that previously recommended limits for strawberries and tomatoes be amended as follows: Commodity Limit Strawberries 1 Tomatoes 2 FURTHER WORK OR INFORMATION Desirable 1. Additional residue data and information on use patterns of thiabendazole on strawberries, tomatoes, cherries and cucumbers from countries other than Denmark and the Netherlands. 2. Information listed as desirable in the 1977 Evaluations. REFERENCES Voldum-Clausen, K. - Experiments on Pesticide Residues. No. S. 415, 416, 419 and 420. (1979) Unpublished, Restricted, Ministry of the Environment, National Food Institute, Division of Pesticides and Contaminants, Morkhoj Bygade 19. DY-2860 Soborg, Denmark.
See Also: Toxicological Abbreviations Thiabendazole (WHO Food Additives Series 39) Thiabendazole (AGP:1970/M/12/1) Thiabendazole (WHO Pesticide Residues Series 1) Thiabendazole (WHO Pesticide Residues Series 2) Thiabendazole (WHO Pesticide Residues Series 5) Thiabendazole (Pesticide residues in food: 1977 evaluations) Thiabendazole (Pesticide residues in food: 1981 evaluations)