PESTICIDE RESIDUES IN FOOD - 1984 Sponsored jointly by FAO and WHO EVALUATIONS 1984 The monographs Data and recommendations of the joint meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Expert Group on Pesticide Residues Rome, 24 September - 3 October 1984 Food and Agriculture Organization of the United Nations Rome 1985 METHAMIDOPHOS Explanation Methamidophos was first evaluated by the 1976 JMPR 1/ at which limits were established for a number of commodities. Additional or revised limits were estimated in 1979 and 1981. On several occasions the CCPR has requested that methamidophos should be considered together with acephate, of which it is a metabolite. To date information has not been sufficient to do that fully, although the JMPR has taken their relationship into account as far as possible. This meeting received additional residue data on methamidophos in egg plants, which are reviewed below. This addendum should be read in conjunction with that on acephate elsewhere in these evaluations. RESIDUES IN FOOD AND THEIR EVALUATION USE PATTERN Mexico The meeting was informed by one manufacturer that Mexican uses on egg plants call for a 0-day pre-harvest interval instead of the 14 days on which the current 0.1 mg/kg limit (1979 JMPR) is based. The original 1 mg/kg estimated by the 1976 JMPR was based on a 7-day pre-harvest interval. Other information on Mexican uses available to the meeting indicates a 1-day interval for a 50% LM formulation and 14 days for a 50% EC formulation (Manual de Plaguicidas, 1981). U.S.A. Geographically restricted uses in the U.S.A. permit 1.1 kg a.i./ha (1 lb a.i./A) 0.75%SP with a 7-day pre-harvest interval. The U.S. tolerance of 1 mg/kg is also designed to accommodate Mexican uses of 150-600 g a.i. EC/ha (5.4 kg a.i./ha total/season). RESIDUES RESULTING FROM SUPERVISED TRIALS The manufacturers have submitted additional residue data on egg plants (Table 1) not previously reviewed by the JMPR (Chevron, 1984; Bayer, 1984). 1/ See Annex 2 for FAO/WHO documentation Table 1. Methamidophos residues on egg plants resulting from supervised field trials. Application Residues,mg/kg Country Year rate no kg a.i./ha formulation 0 1 3 5 7 14 21 Reference Mobay Repts. Mexico 1972- 15 8x0.4-0.6 2% D 0.15 0.13 0.08 0.08 0.07 37305 73 2% dust + EC 1X 0.6EC 1972- 13 9x0.3-0.5 2% D 0.37 0.17 0.19 0.12 0.13 0.05 73 (includes + (0.68) 1 (0.31) - (0.35) (0.22) (0.24) (0.09) 37306 6 appl of EC 2% dust + 2 4x0.6EC Chevron U.S.A.3 1978 3 1.1 4 spray 4769 (4 lb. 0.29 a.i./Gal) 0.30 1979 14 1.1 4 spray 1.9 0.04 0.05 0.03 4770 0.0 0.03 0.07 0.02 1980 10 1.1 4 spray 0.49 0.65 0.15 5142 1.1 0.45 0.12 1979 17 1.1 4 spray 0.23 0.11 0.02 0.38 0.11 0.04 4768 1 Values in parentheses are adjusted to maximum U.S. approved 1.1 kg a.i./ha rate. 2 Last 4 applications were EC 3 Residue data corrected for recovery. The Mexican data do not strictly represent approved uses, since dust applications are included with EC applications. In practice, however, the data are indicative of likely residues from approved uses since all of the last applications were with approved EC formulations. At approved application rates up to 1.1 kg a.i./ha, maximum residues were 0.65 and 0.15 mg/kg at 7- an 14-day intervals respectively, 1.9 mg/kg at 3 days and 0.37 mg/kg (0.68 mg/kg adjusted to maximum U.S. application rates) on the day of last application. Maximum residues of methamidophos in or on kiwi fruit resulting from the use of acephate were 0.012 mg/kg. EVIDENCE OF RESIDUES IN COMMERCE OR AT CONSUMPTION The meeting had information that one 1979 shipment of egg plant of 38 sampled exported to the U.S.A. had over-tolerance residues of 1.9 mg/kg (FDA Surveillance, 1980). APPRAISAL The meeting reviewed additional residue and good agricultural practice information for the use of methamidophos on egg plant and responded to requests of the CCPR to consider acephate and methamidophos together. The meeting reaffirmed its approach to setting separate limits for acephate and methamidophos and concluded that current good agricultural practice information and residue data were still insufficient to permit an effective reassessment of most previously estimated limits. It is noted in the review of acephate elsewhere in these evaluations that methamidophos limits have been estimated for all crops for which there are acceptable limits. In the case of animals, levels of 0.01 mg/kg (limit of determination) were estimated for the carcase meat and fat of cattle, goats and sheep, and for milk. These were apparently based on the studies of methamidophos in the goat reviewed by the 1976 JMPR. Data were also available to that meeting on acephate and methamidophos residues from the simultaneous feeding of acephate and methamidophos to goats and pigs. The 0.01 mg/kg limit for methamidophos in cattle, goats, sheep and milk is probably adequate for residues resulting from the use of acephate or methamidophos on feed items for which there are proposed Codex TMRLs. Studies are not adequate to support methamidophos limits in poultry or eggs, although trace levels have been observed in the muscle and eggs of poultry from high dose levels of acephate (1976 JMPR). Residues data and good agricultural practice information on egg plants provided to the present meeting indicate that the current 0.1 mg/kg limit would not be adequate to accommodate good agricultural practices which include 7-day (and possibly shorter) pre-harvest intervals instead of the 14 days on which the 0.1 mg/kg limit is based. The 1976 evaluations show that even average residues on peppers and tomatoes at a 7-day interval from similar application rates to those approved on egg plant are 0.2 - 1.0 mg/kg and maxima are twice as high. Even after two weeks, maximum tomato and pepper residues exceed 1 mg/kg. These data can reasonably be used to supplement egg plant data. It is also noteworthy that residues found in commerce have exceeded 1 mg/kg, although it is not known whether they resulted from good agricultural practice. Additional data on methamidophos residues resulting from the use of acephate do not indicate any need to revise current methamidophos limits on the commodities concerned. Acephate limits have been estimated for tree tomatoes (tamarillos). Data were also available for methamidophos residues resulting from the use of acephate on tree tomatoes, and these allowed the meeting to estimate a maximum residue level for methamidophos on this commodity. RECOMMENDATIONS The meeting examined residue data from supervised trials reflecting established good agricultural practice and was able to estimate residue levels likely to occur when methamidophos is used in practice and when the reported interval between the last application and harvest is observed. These estimates are recommended as TMRLs. They refer only to methamidophos. Interval between last application and harvest Commodity TMRL (mg/kg) (days) on which recommendations are based Egg plant 1 (previously 0.1) 7 (previously 14) Tree tomato (Tamarillos) * 0.01 14 REFERENCES Bayer, Unpublished Reports made available to the 1984 1984 JMPR by Bayer AG Chevron, Unpublished Reports made available to the 1984 1984 JMPR by Bayer AG FDA Surveillance, Results of FDA Surveillance of Mexican Produce for 1980 Pesticide Residues (Compliance Programs 7305. 008 - Fiscal Year 1979), Bureau of Foods and Office of the Associate Commissioner for Regulatory Affairs, Food and Drug Administration, April 23, 1980. Manual de Plaguicidas Autorizados En 1981 Cultros de Hortalizas Para 1981
See Also: Toxicological Abbreviations Methamidophos (HSG 79, 1993) Methamidophos (ICSC) Methamidophos (JMPR Evaluations 2002 Part II Toxicological) Methamidophos (Pesticide residues in food: 1976 evaluations) Methamidophos (Pesticide residues in food: 1979 evaluations) Methamidophos (Pesticide residues in food: 1981 evaluations) Methamidophos (Pesticide residues in food: 1982 evaluations) Methamidophos (Pesticide residues in food: 1985 evaluations Part II Toxicology) Methamidophos (Pesticide residues in food: 1990 evaluations Toxicology)