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    WHO Pesticide Residues Series, No. 4

    1974 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD

    THE MONOGRAPHS

    The evaluations contained in these monographs were prepared by the
    Joint Meeting of the FAO Working Party of Experts on Pesticide
    Residues and the WHO Expert Committee on Pesticide Residues that met
    in Rome from 2 to 11 December 1974.*

    World Health Organization
    Geneva
    1975

              
    * Pesticide Residues in Food: Report of the 1974 Joint Meeting of the
    FAO Working Party of Experts on Pesticide Residues and the WHO Expert
    Committee on Pesticide Residues, Wld Hlth Org. techn. Rep. Ser., No.
    574; FAO Agricultural Studies, 1975, No. 97.

    These monographs are also issued by the Food and Agriculture
    Organization of the United Nations, Rome, as document
    FAO/AGP/1974/M/11.

    ISBN 92 4 166504 1

    (c) FAO and WHO 1975

    CONTENTS

    List of Attendees

    Introduction

    The Monographs

    Aldrin/dieldrin*

    Amitrole

    Azinphos-methyl*

    Binapacryl*

    Captafol*

    Captan*

    Chinomethionat*

    Chlordane*

    Chlorothalonil

    Chlorpyriphos*

    Cyhexatin*

    2,4-D*

    Dichlofluanid*

    Dichlorvos*

    Dicloran

    Dicofol*

    Dinocap*

    Dithiocarbamates*

    Dodine

    Endosulfan*

    Endrin*

    Fenamiphos

    Fenitrothion*

    Folpet*

    Heptachlor*

    Hexachlorobenzene*

    Leptophos

    Lindane*

    Mancozeb*

    Phosphamidon*

    Pirimiphos-methyl

    Pyrethrins*

    Quintozene*

    Tecnazene


    ANNEX 1 - Index to documentation and summary of recommendations
    concerning acceptable daily intakes, tolerances, and practical residue
    limits, as of December 1974

    ANNEX 2 - References

              

    *Addendum
    

    LIST OF ATTENDEES

    Members of the FAO Working Party of Experts on Pesticide Residues:

    Mr A. Ambrus, Acting Department Head, Central Plant Protection and
    Quarantine Laboratory, Analytical Department of Pesticides, Budapest,
    Hungary

    Dr A. F. H. Besemer, Head, Pesticides Division, Plant Protection
    Service, Ministry of Agriculture, Wageningen, Netherlands

    Dr. G. Bressau, Head, Pesticide Laboratory, Federal Health Office, Max
    von Pettenkofer Institute, Berlin, Federal Republic of Germany

    Mr F. Bro-Rasmussen, Head, Department of Pesticides and Contaminants,
    National Food Institute, Soborg, Denmark (Rapporteur)

    Dr K. A. McCully, Chief, Field Sciences Division, Health Protection
    Branch, Department of National Health and Welfare, Ottawa, Ont.,
    Canada

    Mr J. T. Snelson, Pesticides Coordinator, Department of Agriculture,
    Canberra, ACT, Australia (Chairman)

    Observer invited by FAO:

    Dr A. J. Pieters, Chairman, Codex Committee on Pesticide Residues

    Members of the WHO Expert Committee on Pesticide Residues:*

    Dr E. Astolfi, Professor of Toxicology, University of Buenos Aires,
    Argentina

    Dr L. R. Axelrod, Environmental Protection Agency, Washington, DC, USA
    (Rapporteur)

    Professor I. Nir, Director, Department of Clinical Pharmacology,
    Ministry of Health, Jerusalem, Israel

    Professor F. K. Ohnesorge, Chair of Toxicology, Institute of
    Pharmacology and Toxicology, University of Düsseldorf, Federal
    Republic of Germany

    Dr E. Poulsen, Director, Institute of Toxicology, National Food
    Institute, Soborg, Denmark (Vice-Chairman)

    Professor Dr L. Rosival, Director, Research Institute of Hygiene,
    Bratislava, Czechoslovakia

              
    * Unable to attend: Dr G. Belonozko, All-Union Scientific Institute
    of Hygiene and Toxicology of Pesticides, Polymers, and Plastics,
    VNIIGINTOX, Kiev, Ukrainian SSR

    Professor R. Truhaut, Director, Toxicological Research Centre, Faculty
    of Pharmaceutical and Biological Sciences, René Descartes University,
    Paris, France

    Secretariat:

    Dr R. L. Baron, National Environmental Research Center, Pesticides and
    Toxic Substances Effects Laboratory, Environmental Protection Agency,
    Research Triangle Park, NC, USA (Temporary Adviser)

    Mr J. Cummings, Pesticides Specialist, UNDP/FAO Project THA 68/526,
    Bangkok, Thailand (Consultant)

    Dr L. G. Ladomery, Food Standards Officer, Food Standards and Control
    Service, FAO, Rome, Italy

    Dr F. C. Lu, Chief, Food Additives, WHO, Geneva, Switzerland (Joint
    Secretary)

    Mr A. F. Machin, Senior Research Officer, Central Veterinary
    Laboratory, Ministry of Agriculture, Weybridge, Surrey, England
    (Consultant)

    Dr R. Montesano, Chemical Carcinogenesis Unit, International Agency
    for Research on Cancer, Lyon, France

    Dr S. D. Murphy, Associate Professor of Toxicology, Harvard University
    School of Public Health, Boston, MA, USA (Temporary Adviser)

    Dr E. E. Turtle, Pesticides Specialist, Plant Protection Service, FAO,
    Rome, Italy (Joint Secretary)

    Dr G. Vettorazzi, Scientist, Food Additives, WHO, Geneva, Switzerland

    INTRODUCTION

         A Joint Meeting of the FAO Working Party of Experts on Pesticide
    Residues and the WHO Expert Committee on Pesticide Residues was held
    in Rome from 2 to 11 December 1974. The general considerations,
    including the principles adopted for the evaluations and a summary of
    the results of evaluations on a number of pesticide residues, appear
    in the publication, "Report of the 1974 Joint Meeting of the FAO
    Working Party of Experts on Pesticide Residues and the WHO Expert
    Committee on Pesticide Residues".1 Additional information, including
    previously unpublished summaries of data considered by the Joint
    Meeting in arriving at recommendations for acceptable daily intakes,
    tolerances and methods of analysis, is to be found in this document.

         Many of the compounds considered at this meeting have been
    previously evaluated in earlier publications. If only a limited amount
    of additional information on these compounds has become available in
    the intervening years, only this latter information is summarized in
    the pertinent monograph, and reference is made to the previously
    published evaluation, which should also be consulted by the reader who
    wishes to obtain a complete evaluation of the compound. Such monograph
    addenda are indicated by an asterisk in the "Contents", p. iii. If a
    large amount of data has become available since the previously
    published evaluation, or if the compound was first considered by the
    Joint Meeting in 1974, the pertinent monograph is reproduced in its
    entirety.

         As much relevant information as possible has been included in the
    monographs. This has been obtained from the published literature
    wherever possible, but other sources of information have also been
    used. Early and complete publication of the results of research in
    this field is very important, particularly of that part which could
    form the basis for estimation of acceptable daily intakes and
    appropriate tolerances.

         Publication allows the research to be scrutinized and criticized
    by scientists from disciplines not necessarily represented at the
    meeting. Data contained in unpublished reports, because they may
    include more detail than published work, are often acceptable.
    However, such reports must be complete and nonconfidential and
    indicate authorship.

         Two annexes have been included at the end of this series of
    monographs. Annex I is a reproduction of Annex I in the Report of the
    1974 Joint Meeting,1 and gives the recommendations concerning


              

    1 Pesticide residues in food. Report of the 1974 Joint Meeting of the
    FAO Working Party of Experts on Pesticide Residues and the WHO Expert
    Committee on Pesticide Residues, Wld. Hlth Org. techn. Rep. Ser.,
    No. 574; FAO Agricultural Studies, No. 97.

    acceptable daily intakes and residue limits made at the 1974 Meeting.
    Annex II gives bibliographic references of all previous Reports and
    monographs and other publications of a general nature.

    NOTE TO THE READER

         Any comments on evaluation for acceptable daily intake should be
    addressed to:

         Food Additives Unit
         World Health Organization
         Geneva, Switzerland

         Any comments on residues in food and their evaluation should be
    addressed to:

         Plant Protection Service
         Plant Production and Protection Division
         Food and Agriculture Organization
         Rome, Italy






















    See Also:
       Toxicological Abbreviations