ICSC 0422 - COUMAPHOS

COUMAPHOS	ICSC: 0422 (April 2013)
O-3-Chloro-4-methyl-2-oxo-2H-chromen-7-yl O,O-diethyl phosphorothioate Phosphorothioic acid O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl ester O,O-Diethyl O-(3-chloro-4-methyl-7-coumarinyl)phosphorothioate O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate

CAS #: 56-72-4

UN #: 3027

EC Number: 200-285-3

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Not combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting.		In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep drums, etc., cool by spraying with water.

PREVENT DISPERSION OF DUST! AVOID ALL CONTACT! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN! FIRST AID: USE PERSONAL PROTECTION.
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Headache. Sweating. Weakness. Nausea. Vomiting. Pupillary constriction, muscle cramp, excessive salivation. Laboured breathing. Unconsciousness.	Use local exhaust or breathing protection.	Fresh air, rest. Artificial respiration may be needed. No mouth-to-mouth artificial respiration. Refer immediately for medical attention.
Skin	MAY BE ABSORBED! Further see Inhalation.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . See Notes.
Eyes	Redness.	Wear face shield or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Abdominal cramps. Diarrhoea. Further see Inhalation.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Give a slurry of activated charcoal in water to drink. NO mouth-to-mouth artificial respiration. Refer immediately for medical attention.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance and protective clothing. Do NOT wash away into sewer. Collect the spilled substance into containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Fatal if swallowed or if inhaled Harmful in contact with skin Very toxic to aquatic life with long lasting effects Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: II
STORAGE
Separated from food and feedstuffs. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.
PACKAGING
Do not transport with food and feedstuffs. Marine pollutant.

COUMAPHOS

ICSC: 0422

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS CRYSTALS WITH CHARACTERISTIC ODOUR. Physical dangers Chemical dangers Decomposes on heating. This produces toxic fumes including sulfur oxides, phosphorus oxides and hydrogen chloride.	Formula: C₁₄H₁₆ClO₅PS Molecular mass: 362.78 Melting point: 91°C Density: 1.47 g/cm³ Solubility in water: none Vapour pressure at 20°C: negligible Octanol/water partition coefficient as log Pow: 4.13

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS CRYSTALS WITH CHARACTERISTIC ODOUR.

Physical dangers

Chemical dangers
Decomposes on heating. This produces toxic fumes including sulfur oxides, phosphorus oxides and hydrogen chloride.

Formula: C₁₄H₁₆ClO₅PS
Molecular mass: 362.78
Melting point: 91°C
Density: 1.47 g/cm³
Solubility in water: none
Vapour pressure at 20°C: negligible
Octanol/water partition coefficient as log Pow: 4.13

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. Effects of short-term exposure Cholinesterase inhibition. The substance may cause effects on nervous system. The effects may be delayed. Medical observation is indicated.	Inhalation risk Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. Effects of long-term or repeated exposure Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Effects of short-term exposure
Cholinesterase inhibition. The substance may cause effects on nervous system. The effects may be delayed. Medical observation is indicated.

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 0.05 mg/m³, as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued

ENVIRONMENT
The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to fish, crustacea, birds and mammals. Bioaccumulation of this chemical may occur in fish. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

ENVIRONMENT

The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to fish, crustacea, birds and mammals. Bioaccumulation of this chemical may occur in fish. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

NOTES
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Carrier solvents used in commercial formulations may change physical and toxicological properties. Isolate contaminated clothing by sealing in a bag or other container.

ADDITIONAL INFORMATION

EC Classification
Symbol: T+, N; R: 21-28-50/53; S: (1/2)-28-36/37-45-60-61

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    See Also:
       Toxicological Abbreviations
       Coumaphos (FAO/PL:1968/M/9/1)
       Coumaphos (WHO Pesticide Residues Series 2)
       Coumaphos (WHO Pesticide Residues Series 5)
       Coumaphos (Pesticide residues in food: 1978 evaluations)
       Coumaphos (Pesticide residues in food: 1980 evaluations)
       Coumaphos (Pesticide residues in food: 1983 evaluations)
       Coumaphos (Pesticide residues in food: 1990 evaluations Toxicology)