ICSC 0189 - PHOSPHAMIDON

PHOSPHAMIDON	ICSC: 0189 (October 2005)
2-Chloro-2-diethylcarbamoyl-1-methylvinyl dimethyl phosphate 2-Chloro-3-(diethylamino)-1-methyl-3-oxo-1-propenyl dimethyl phosphate Dimethyl phosphate ester 2-chloro-N,N-diethyl-3-hydroxycrotonamide O,O-Dimethyl-O-(2-chloro-2-diethylcarbamoyl-1-methylvinyl) phosphate

CAS #: 13171-21-6

UN #: 3018

EC Number: 236-116-5

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.		In case of fire in the surroundings, use appropriate extinguishing media.

STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN! IN ALL CASES CONSULT A DOCTOR!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Sweating. Muscle twitching. Pupillary constriction, muscle cramp, excessive salivation. Diarrhoea. Dizziness. Laboured breathing. Vomiting. Convulsions. Unconsciousness. Symptoms may be delayed. See Notes.	Use ventilation, local exhaust or breathing protection.	Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin	MAY BE ABSORBED! Further see Inhalation.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Eyes	Redness. Pain.	Wear face shield or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Abdominal cramps. Further see Inhalation.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention. See Notes.

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable non-metallic containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.	According to UN GHS Criteria Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: II
STORAGE
Store in an area without drain or sewer access. Well closed. Keep in a well-ventilated room. Separated from bases and food and feedstuffs.
PACKAGING
Do not transport with food and feedstuffs. Severe marine pollutant.

PHOSPHAMIDON

ICSC: 0189

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance COLOURLESS-TO-YELLOW OILY LIQUID. Physical dangers Chemical dangers Decomposes on heating and on burning. This produces highly toxic fumes including phosphorus oxides, hydrogen chloride and nitrogen oxides. Reacts with bases (hydrolysis). Attacks metals such as iron, tin and aluminium.	Formula: C₁₀H₁₉ClNO₅P Molecular mass: 299.7 Boiling point at 0.2kPa: 162°C Melting point: -45°C Relative density (water = 1): 1.2 Solubility in water: miscible Vapour pressure, Pa at 20°C: 0.0033 Octanol/water partition coefficient as log Pow: 0.8

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS-TO-YELLOW OILY LIQUID.

Physical dangers

Chemical dangers
Decomposes on heating and on burning. This produces highly toxic fumes including phosphorus oxides, hydrogen chloride and nitrogen oxides. Reacts with bases (hydrolysis). Attacks metals such as iron, tin and aluminium.

Formula: C₁₀H₁₉ClNO₅P
Molecular mass: 299.7
Boiling point at 0.2kPa: 162°C
Melting point: -45°C
Relative density (water = 1): 1.2
Solubility in water: miscible
Vapour pressure, Pa at 20°C: 0.0033
Octanol/water partition coefficient as log Pow: 0.8

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. Effects of short-term exposure The substance is irritating to the eyes. The substance may cause effects on the nervous system. This may result in convulsions, respiratory depression and death. Exposure at high levels could cause death. Cholinesterase inhibition. The effects may be delayed. Medical observation is indicated.	Inhalation risk Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying. Effects of long-term or repeated exposure Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Effects of short-term exposure
The substance is irritating to the eyes. The substance may cause effects on the nervous system. This may result in convulsions, respiratory depression and death. Exposure at high levels could cause death. Cholinesterase inhibition. The effects may be delayed. Medical observation is indicated.

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying.

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms.

OCCUPATIONAL EXPOSURE LIMITS

ENVIRONMENT
The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to birds and bees. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

NOTES
Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Commercial product is a mixture of isomers. Carrier solvents used in commercial formulations may change physical and toxicological properties. Do NOT take working clothes home.

ADDITIONAL INFORMATION

EC Classification
Symbol: T+, N; R: 24-28-68-50/53; S: (1/2)-23-36/37-45-60-61

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    See Also:
       Toxicological Abbreviations
       Phosphamidon (PIM 454)
       Phosphamidon (FAO Meeting Report PL/1965/10/1)
       Phosphamidon (FAO/PL:CP/15)
       Phosphamidon (FAO/PL:1968/M/9/1)
       Phosphamidon (FAO/PL:1969/M/17/1)
       Phosphamidon (WHO Pesticide Residues Series 2)
       Phosphamidon (WHO Pesticide Residues Series 4)
       Phosphamidon (Pesticide residues in food: 1982 evaluations)
       Phosphamidon (Pesticide residues in food: 1986 evaluations Part II Toxicology)