FAO/PL:1969/M/17/1

    WHO/FOOD ADD./70.38

    1969 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD

    THE MONOGRAPHS

    Issued jointly by FAO and WHO

    The content of this document is the result of the deliberations of the
    Joint Meeting of the FAO Working Party of Experts and the WHO Expert
    Group on Pesticide Residues, which met in Rome, 8 - 15 December 1969.

    FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS

    WORLD HEALTH ORGANIZATION

    Rome, 1970

    PHOSPHAMIDON

    Explanation

    This compound was considered at the Joint Meetings in 1965 when a
    monograph was issued (FAO/WHO, 1965b), and in 1966 and 1968 when
    addenda were issued (FAO/WHO, 1967b and 1969b).* The latter addendum
    (page 262) expressed the need for "an analytical method that is
    specific for phosphamidon and its N-de-ethyl derivative". Information
    received from CIBA Ltd. concerning such a method was drawn to the
    attention of the 1969 Joint Meeting which decided to issue this
    addendum on the subject.

    METHOD OF RESIDUE ANALYSIS

    The plant or other material is extracted with acetonitrile or
    methylene chloride. After portioning between solvent phases, the
    extract in chromatographed on a silica gel column and then on a
    thin-layer chromatoplate. The appropriate portions of adsorbent are
    removed from the plate and the compounds elated. Quantitative
    determinations are then made by gas chromatography using a phosphorus
    flame photometric detector.

    The procedure will determine both cis-and trans-phosphamidon and also
    its N-des-ethyl derivative. Sensitivity is about 0.02 to 0.04 ppm and
    the method is considered to be generally satisfactory.

    REFERENCES

    CIBA Ltd. Determination of phosphamidon residues (Unpub, rept.).
    1969

                 
    * See Appendix II
    

    See Also:
       Toxicological Abbreviations
       Phosphamidon (ICSC)
       Phosphamidon (PIM 454)
       Phosphamidon (FAO Meeting Report PL/1965/10/1)
       Phosphamidon (FAO/PL:CP/15)
       Phosphamidon (FAO/PL:1968/M/9/1)
       Phosphamidon (WHO Pesticide Residues Series 2)
       Phosphamidon (WHO Pesticide Residues Series 4)
       Phosphamidon (Pesticide residues in food: 1982 evaluations)
       Phosphamidon (Pesticide residues in food: 1986 evaluations Part II Toxicology)