FAO, PL:CP/15
    WHO/Food Add./67.32

    EVALUATION OF SOME PESTICIDE RESIDUES IN FOOD

    The content of this document is the result of the deliberations of the
    Joint Meeting of the FAO Working Party and the WHO Expert Committee on
    Pesticide Residues, which met in Geneva, 14-21 November 1966.1

             
    1 Report of a Joint Meeting of the FAO Working Party and the WHO
    Expert Committee on Pesticide Residues, FAO Agricultural Studies, in
    press; Wld Hlth Org. techn. Rep. Ser., 1967, in press

    DIMETHOATE

    This pesticide was evaluated by the Joint Meeting of the FAO Committee
    on Pesticides in Agriculture and the WHO Expert Committee on Pesticide
    Residues in its 1965 report (FAO Meeting Report No. PL/1965/10/1;
    WHO/Food Add./27.65). No additional data on this compound were
    considered in 1966.

    Comments

    Short-term studies have been made on a number of species, in the rat
    for as long as one year. Some observations have also been made in man,
    at 3 dose levels; however, except at the lowest dose level, the number
    of subjects was too small for evaluation.

    It was noted that in the experiment on guinea-pigs fed with treated
    vegetation the inhibition of cholinesterase activity produced by the
    residue in the plant was equivalent to that produced by laboratory
    grade dimethoate.

    TOXICOLOGICAL EVALUATION

    Level causing no toxicological effect

    Rat. 5 ppm in the diet according to the weight of the animals used
    in the experiment is approximately equivalent to 0.4 mg/kg
    body-weight.

    Man. 0.04 mg/kg body-weight per day.

    Estimate of acceptable daily intake for man

    0-0.004 mg/kg body-weight.

    Further work desirable

    Chemical composition and toxicity of the residues. Reproduction
    studies in the rat.
    

    See Also:
       Toxicological Abbreviations
       Dimethoate (EHC 90, 1989)
       Dimethoate (HSG 20, 1988)
       Dimethoate (ICSC)
       Dimethoate (FAO Meeting Report PL/1965/10/1)
       Dimethoate (FAO/PL:1967/M/11/1)
       Dimethoate (JMPR Evaluations 2003 Part II Toxicological)
       Dimethoate (AGP:1970/M/12/1)
       Dimethoate (Pesticide residues in food: 1983 evaluations)
       Dimethoate (Pesticide residues in food: 1984 evaluations)
       Dimethoate (Pesticide residues in food: 1984 evaluations)
       Dimethoate (Pesticide residues in food: 1987 evaluations Part II Toxicology)
       Dimethoate (Pesticide residues in food: 1996 evaluations Part II Toxicological)