WHO Pesticide Residues Series, No. 3
1973 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD
THE MONOGRAPHS
The evaluations contained in these monographs were prepared by the
Joint Meeting of the FAO Working Party of Experts on Pesticide
Residues and the WHO Expert Committee on Pesticide Residues that met
in Geneva from 26 November to 5 December 1973.
World Health Organization
Geneva
1974
1 Pesticide Residues in Food: Report of the 1973 Joint Meeting of
the FAO Working Party of Experts on Pesticide Residues and the WHO
Expert Committee on Pesticide Residues, Wld Hlth Org. techn. Rep.
Ser., 1974, No. 545: FAO Agricultural Studies, 1974, No. 92.
These monographs are also issued by the Food and Agriculture
Organization of the United Nations, Rome, as document
FAO/AGP/1973/M/9/1.
ISBN 92 4 166503 3
(C) FAO and WHO 1974
CONTENTS
List of attendees
Introduction
The Monographs:
Azinphos-ethyl
Azinphos-methyl*
Benomyl
BHC (technical)*
Bromopropylate
Camphechlor* (Toxaphene)
Captafol*
Captan*
Carbaryl*
Carbendazim
Demeton-S-methyl and related compounds
Disulfoton
Folpet*
Formothion*
Hexachlorobenzene (HCB)*
Lindane*
Malathion*
Propoxur
Quintozene*
Thiometon
Thiophanate-methyl
Tricyclohexyltin hydroxide*
Vamidothion
ANNEX I. RECOMMENDATIONS CONCERNING ACCEPTABLE DAILY
INTAKES AND RESIDUE LIMITS MADE AT THE 1973 MEETING
ANNEX II. REFERENCES
Index
* Addendum.
LIST OF ATTENDEES
Members of the FAO Working Party of Experts on Pesticide Residues
Mr A. Ambrus, Acting Department Head, Central Plant Protection and
Quarantine Laboratory, Analytical Department of Pesticides, Budapest,
Hungary
Dr A. F. H. Besemer, Head, Pesticides Division, Plant Protection
Service, Ministry of Agriculture, Wageningen, Netherlands
Mr F. Bro-Rasmussen, Head, Department of Pesticides, Food Additives
and Contaminants, National Food Institute, Holte, Denmark
Dr K. Glogowski, Deputy Director (Scientific), Plant Protection
Institute, Poznan, Poland
Dr K. R. Hill, Chief, Analytical Chemistry Laboratory, Agricultural
Environmental Quality Institute - ARS, Beltsville, Md, USA
(Vice-Chairman)
Mr J. T. Snelson, Pesticides Co-ordinator, Department of Primary
Industry, Canberra, Australia (Rapporteur)
Observer invited by FAO
Mr A. J. Pieters, Chairman, Codex Committee on Pesticide Residues
Members of the WHO Expert Committee on Pesticide Residues
Dr G. V. Graceva, All-Union Research Institute for Hygiene and
Toxicology of Pesticides and Polymers, Kiev, Ukrainian SSR
Dr F. P. Kalojanova-Simeonova, Professor of Toxicology, Director,
Research Institute of Hygiene and Occupational Health, Sofia, Bulgaria
Dr S. D. Murphy, Associate Professor of Toxicology, Harvard
University, School of Public Health, Boston, Mass., USA (Chairman)
Professor I. Nir, Director, Department of Clinical Pharmacology,
Ministry of Health, Jerusalem, Israel (Rapporteur)
Professor F. K. Ohnesorge, Head, Department of Toxicology, Institute
of Pharmacology, University of Kiel, Federal Republic of Germany
Dr E. Poulsen, Director, Institute of Toxicology, National Food
Institute, Soborg, Denmark
Dr F. J. C. Roe, Member of the Institute of Cancer Research, London,
England
Professor A. H. Sundwall, Department of Pharmacology, University of
Uppsala, Sweden
Secretariat
Dr R. L. Baron, Environmental Protection Agency, Pesticide and Toxic
Substances Effects Laboratory, Research Triangle Park, N.C., USA
(Temporary Adviser)
Mr J. Cummings, Chief, Chemistry Branch, Registration Division, Office
of Pesticide Programmes, US Environmental Protection Agency,
Washington, DC., USA (Consultant)
Dr H. Falk, Environmental Pollution, WHO, Geneva, Switzerland
Dr F. C. Lu, Chief Scientist, Food Additives, WHO, Geneva, Switzerland
(Joint Secretary)
Mr A. F. Machin, Senior Research Officer, Central Veterinary
Laboratory, Ministry of Agriculture, Weybridge, Surrey, England
(Consultant)
Dr M. Sharratt, Senior Medical Officer, Department of Health and
Social Security, London, England (Temporary Adviser)
Dr E. E. Turtle, Pesticides Specialist, Plant Protection Service, FAO,
Rome, Italy (Joint Secretary)
Dr G. Vettorazzi, Scientist, Food Additives, WHO, Geneva, Switzerland
INTRODUCTION
A Joint Meeting of the FAO Working Party of Experts on Pesticide
Residues and the WHO Expert Committee on Pesticide Residues was held
in Geneva from 26 November to 5 December 1973. The general
considerations, including the principles adopted for the evaluations
and a summary of the results of evaluations on a number of pesticide
residues, appear in the publication, "Report of the 1973 Joint Meeting
of the FAO Working Party of Experts on Pesticide Residues and the WHO
Expert Committee on Pesticide Residues".1 Additional information,
including previously unpublished summaries of data considered by the
Joint Meeting in arriving at recommendations for acceptable daily
intakes, tolerances and methods of analysis, is to be found in this
document.
Many of the compounds considered at this meeting have been
previously evaluated in earlier publications. If only a limited amount
of additional information on these compounds has become available in
the intervening years, only this latter information is summarized in
the pertinent monograph, and reference is made to the previously
published evaluation, which should also be consulted by the reader who
wishes to obtain a complete evaluation of the compound. Such monograph
addenda are indicated by an asterisk in the "Contents", p. iii. If a
large amount of data has become available since the previously
published evaluation, or if the compound was first considered by the
Joint Meeting in 1973, the pertinent monograph is reproduced in its
entirety.
As much relevant information as possible has been included in the
monographs. This has been obtained from the published literature
wherever possible, but other sources of information have also been
used. Early and complete publication of the results of research in
this field is very important, particularly of that part which could
form the basis for estimation of acceptable daily intakes and
appropriate tolerances.
Publication allows the research to be scrutinized and criticized
by scientists from disciplines not necessarily represented at the
meeting. Data contained in unpublished reports, because they may
include more detail than published work, are often acceptable.
However, such reports must be complete and nonconfidential and
indicate authorship.
1 Pesticide residues in food. Report of the 1973 Joint Meeting of the
FAO Working Party of Experts on Pesticide Residues and the WHO Expert
Committee on Pesticide Residues, Wld Hlth Org. techn. Rep. Ser., No.
545; FAO Agricultural Studies, No. 92.
Two annexes have been included at the end of this series of
monographs. Annex I is a reproduction of Annex I in the Report of the
1973 Joint Meeting,1 and gives the recommendations concerning
acceptable daily intakes and residue limits made at the 1973 Meeting.
Annex II gives bibliographic references of all previous Reports and
monographs and other publications of a general nature.
NOTE TO THE READER
Any comments on evaluation for acceptable daily intakes should be
addressed to:
Food Additives Unit
World Health Organization
Geneva, Switzerland,
Any comments on residues in food and their evaluation should be
addressed to:
Plant Protection Service
Plant Production and Protection Division
Food and Agriculture Organization
Rome, Italy
1 Pesticide residues in food. Report of the 1973 Joint Meeting of the
FAO Working Party of Experts on Pesticide Residues and the WHO Expert
Committee on Pesticide Residues, Wld Hlth Org. techn. Rep. Ser., No.
545; FAO Agricultural Studies, No. 92.
See Also:
Toxicological Abbreviations