WHO Pesticide Residues Series, No. 4
1974 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD
THE MONOGRAPHS
The evaluations contained in these monographs were prepared by the
Joint Meeting of the FAO Working Party of Experts on Pesticide
Residues and the WHO Expert Committee on Pesticide Residues that met
in Rome from 2 to 11 December 1974.*
World Health Organization
Geneva
1975
* Pesticide Residues in Food: Report of the 1974 Joint Meeting of the
FAO Working Party of Experts on Pesticide Residues and the WHO Expert
Committee on Pesticide Residues, Wld Hlth Org. techn. Rep. Ser., No.
574; FAO Agricultural Studies, 1975, No. 97.
These monographs are also issued by the Food and Agriculture
Organization of the United Nations, Rome, as document
FAO/AGP/1974/M/11.
ISBN 92 4 166504 1
(c) FAO and WHO 1975
CONTENTS
List of Attendees
Introduction
The Monographs
Aldrin/dieldrin*
Amitrole
Azinphos-methyl*
Binapacryl*
Captafol*
Captan*
Chinomethionat*
Chlordane*
Chlorothalonil
Chlorpyriphos*
Cyhexatin*
2,4-D*
Dichlofluanid*
Dichlorvos*
Dicloran
Dicofol*
Dinocap*
Dithiocarbamates*
Dodine
Endosulfan*
Endrin*
Fenamiphos
Fenitrothion*
Folpet*
Heptachlor*
Hexachlorobenzene*
Leptophos
Lindane*
Mancozeb*
Phosphamidon*
Pirimiphos-methyl
Pyrethrins*
Quintozene*
Tecnazene
ANNEX 1 - Index to documentation and summary of recommendations
concerning acceptable daily intakes, tolerances, and practical residue
limits, as of December 1974
ANNEX 2 - References
*Addendum
LIST OF ATTENDEES
Members of the FAO Working Party of Experts on Pesticide Residues:
Mr A. Ambrus, Acting Department Head, Central Plant Protection and
Quarantine Laboratory, Analytical Department of Pesticides, Budapest,
Hungary
Dr A. F. H. Besemer, Head, Pesticides Division, Plant Protection
Service, Ministry of Agriculture, Wageningen, Netherlands
Dr. G. Bressau, Head, Pesticide Laboratory, Federal Health Office, Max
von Pettenkofer Institute, Berlin, Federal Republic of Germany
Mr F. Bro-Rasmussen, Head, Department of Pesticides and Contaminants,
National Food Institute, Soborg, Denmark (Rapporteur)
Dr K. A. McCully, Chief, Field Sciences Division, Health Protection
Branch, Department of National Health and Welfare, Ottawa, Ont.,
Canada
Mr J. T. Snelson, Pesticides Coordinator, Department of Agriculture,
Canberra, ACT, Australia (Chairman)
Observer invited by FAO:
Dr A. J. Pieters, Chairman, Codex Committee on Pesticide Residues
Members of the WHO Expert Committee on Pesticide Residues:*
Dr E. Astolfi, Professor of Toxicology, University of Buenos Aires,
Argentina
Dr L. R. Axelrod, Environmental Protection Agency, Washington, DC, USA
(Rapporteur)
Professor I. Nir, Director, Department of Clinical Pharmacology,
Ministry of Health, Jerusalem, Israel
Professor F. K. Ohnesorge, Chair of Toxicology, Institute of
Pharmacology and Toxicology, University of Düsseldorf, Federal
Republic of Germany
Dr E. Poulsen, Director, Institute of Toxicology, National Food
Institute, Soborg, Denmark (Vice-Chairman)
Professor Dr L. Rosival, Director, Research Institute of Hygiene,
Bratislava, Czechoslovakia
* Unable to attend: Dr G. Belonozko, All-Union Scientific Institute
of Hygiene and Toxicology of Pesticides, Polymers, and Plastics,
VNIIGINTOX, Kiev, Ukrainian SSR
Professor R. Truhaut, Director, Toxicological Research Centre, Faculty
of Pharmaceutical and Biological Sciences, René Descartes University,
Paris, France
Secretariat:
Dr R. L. Baron, National Environmental Research Center, Pesticides and
Toxic Substances Effects Laboratory, Environmental Protection Agency,
Research Triangle Park, NC, USA (Temporary Adviser)
Mr J. Cummings, Pesticides Specialist, UNDP/FAO Project THA 68/526,
Bangkok, Thailand (Consultant)
Dr L. G. Ladomery, Food Standards Officer, Food Standards and Control
Service, FAO, Rome, Italy
Dr F. C. Lu, Chief, Food Additives, WHO, Geneva, Switzerland (Joint
Secretary)
Mr A. F. Machin, Senior Research Officer, Central Veterinary
Laboratory, Ministry of Agriculture, Weybridge, Surrey, England
(Consultant)
Dr R. Montesano, Chemical Carcinogenesis Unit, International Agency
for Research on Cancer, Lyon, France
Dr S. D. Murphy, Associate Professor of Toxicology, Harvard University
School of Public Health, Boston, MA, USA (Temporary Adviser)
Dr E. E. Turtle, Pesticides Specialist, Plant Protection Service, FAO,
Rome, Italy (Joint Secretary)
Dr G. Vettorazzi, Scientist, Food Additives, WHO, Geneva, Switzerland
INTRODUCTION
A Joint Meeting of the FAO Working Party of Experts on Pesticide
Residues and the WHO Expert Committee on Pesticide Residues was held
in Rome from 2 to 11 December 1974. The general considerations,
including the principles adopted for the evaluations and a summary of
the results of evaluations on a number of pesticide residues, appear
in the publication, "Report of the 1974 Joint Meeting of the FAO
Working Party of Experts on Pesticide Residues and the WHO Expert
Committee on Pesticide Residues".1 Additional information, including
previously unpublished summaries of data considered by the Joint
Meeting in arriving at recommendations for acceptable daily intakes,
tolerances and methods of analysis, is to be found in this document.
Many of the compounds considered at this meeting have been
previously evaluated in earlier publications. If only a limited amount
of additional information on these compounds has become available in
the intervening years, only this latter information is summarized in
the pertinent monograph, and reference is made to the previously
published evaluation, which should also be consulted by the reader who
wishes to obtain a complete evaluation of the compound. Such monograph
addenda are indicated by an asterisk in the "Contents", p. iii. If a
large amount of data has become available since the previously
published evaluation, or if the compound was first considered by the
Joint Meeting in 1974, the pertinent monograph is reproduced in its
entirety.
As much relevant information as possible has been included in the
monographs. This has been obtained from the published literature
wherever possible, but other sources of information have also been
used. Early and complete publication of the results of research in
this field is very important, particularly of that part which could
form the basis for estimation of acceptable daily intakes and
appropriate tolerances.
Publication allows the research to be scrutinized and criticized
by scientists from disciplines not necessarily represented at the
meeting. Data contained in unpublished reports, because they may
include more detail than published work, are often acceptable.
However, such reports must be complete and nonconfidential and
indicate authorship.
Two annexes have been included at the end of this series of
monographs. Annex I is a reproduction of Annex I in the Report of the
1974 Joint Meeting,1 and gives the recommendations concerning
1 Pesticide residues in food. Report of the 1974 Joint Meeting of the
FAO Working Party of Experts on Pesticide Residues and the WHO Expert
Committee on Pesticide Residues, Wld. Hlth Org. techn. Rep. Ser.,
No. 574; FAO Agricultural Studies, No. 97.
acceptable daily intakes and residue limits made at the 1974 Meeting.
Annex II gives bibliographic references of all previous Reports and
monographs and other publications of a general nature.
NOTE TO THE READER
Any comments on evaluation for acceptable daily intake should be
addressed to:
Food Additives Unit
World Health Organization
Geneva, Switzerland
Any comments on residues in food and their evaluation should be
addressed to:
Plant Protection Service
Plant Production and Protection Division
Food and Agriculture Organization
Rome, Italy