1976 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD THE MONOGRAPHS The content of this document is the result of the deliberations of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues and the Environment and the WHO Expert Group on Pesticide Residues, which met in Rome, 22 - 30 November 1976.* FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS Rome, 1977 * Pesticide Residues in Food: Report of the 1976 Joint Meeting of the FAO Panel of Experts on Pesticide Residues and the Environment and the WHO Expert Group on Pesticide Residues, WHO Technical Report, Series No. 612, 1977; Plant Production and Protection Series No. 8, 1977. This document contains summaries of data considered by the Joint Meeting of the FAO Panel of Experts on Pesticide Residues and the Environment and the WHO Expert Group on Pesticide Residues in arriving at recommendations for acceptable daily intakes, tolerances and methods of analysis. A summary report of the 1976 Joint Meeting* has also been published which contains general considerations, including the principles adopted for the evaluation and a summary of the results of evaluation of a number of pesticide residues. * Pesticide Residues in Food. Report of the 1976 Joint Meeting of the FAO Panel of Experts on Pesticide Residues and the Environment and the WHO Expert Group on Pesticide Residues, WHO Technical Report Series No. 612, 1977; Plant Production and Protection Series No. 8, 1977. M-84 ISBN 92-5-100442-0 (C) FAO and WHO 1977 CONTENTS List of attendees Introduction The Monographs Acephate Bioresmethrin* Captafol* Carbaryl* Carbendazim* Carbofuran (text is not available) Carbophenothion* Cartap Chlormequat* Dialifos Diphenylamine* Diquat* Dodine* Edifenphos Fenitrothion* Maleic hydrazide Methamidophos Methomyl* Paraquat* Phosalone* Phosmet Pirimicarb Pirimiphos-methyl* Thiometon* ANNEX 1 - Acceptable daily intakes, residue limits and guideline levels recommended at the 1976 Meeting * Addendum LIST OF ATTENDEES Members of the FAO Panel of Experts on Pesticide Residues and the Environment: Dr A.F.H. Besemer, Head, Pesticides Division, Plant Protection Service, Ministry of Agriculture, Wageningen, Netherlands Professor G. Bressau, Head, Pesticides Unit, Division of Food Chemistry, Federal Health Office, Berlin (West) Mr F. Bro-Rasmusen, National Food Institute, Division of Pesticides and Contaminants, Soborg, Copenhagen, Denmark (Rapporteur) Mr J.G. Cummings, Chief, Chemistry Branch, Registration Division, Office of Pesticide Programs, Environmental Protection Agency, Washington, DC, USA Mr J.T. Snelson, Pesticides Coordinator, Department of Primary Industry, Canberra, Australia (Chairman) Dr E.M. Thain, Deputy Directory Tropical Products Institute, London, England Members of the WHO Expert Group on Pesticide Residues: Dr V. Benes, Chief, Toxicology Department, Institute of Hygiene and Epidemiology, Prague, Czechoslovakia (Rapporteur) Mr D.J. Clegg, Pesticide Section, Toxicological Evaluation Division, Health Protection Branch, Department of National Health and Welfare, Ottawa, Canada (Vice-Chairman) Professor I. Nir, Department of Clinical Pharmacology, Ministry of Health, Jerusalem, Israel Professor F.K. Ohnesorge, Pharmacological and Technological Institute, Düsseldorf, Federal Republic of Germany Professor C. Schlatter, Institute of Toxicology, Federal Polytechnic, and University of Zürich, Schwerzenbach, Zürich, Switzerland Dr M. van Logten, Laboratory for General Toxicology, National Institute of Public Health, Bilthoven, Netherlands Observer invited by FAO: Dr A.J. Pieters, Chairman, Codex Committee on Pesticide Residues, Directorate of Public Health, Foodstuffs Division, Leidschendam, Netherlands Secretariat: Dr C. Agthe, Chief, Food Additives, WHO, Geneva, Switzerland Dr R. Baron, Health Effects Research Laboratory, Environmental Research Center, United States Environmental Protection Agency, Research Triangle Park, USA (Temporary Adviser) Dr L.G. Ladomery, Joint FAO/WHO Food Standards Programme, Rome, Italy Dr R. Leski, Chemical Residue and Pollution Section, Joint FAO/IAEA Division of Atomic Energy in Agriculture, International Atomic Energy Agency, Vienna, Austria Mr A.F. Machin, Senior Research Officer, Central Veterinary Laboratory, Ministry of Agriculture, Weybridge, England (Consultant) Dr E. Middleton, Food Directorate, Health Protection Branch, Department of National Health and Welfare, Ottawa (Temporary Adviser) Dr Orville E. Paynter, Chief, Toxicology Branch, Registration Division, Office of Pesticide Programs, US Environmental Protection Agency, Washington, DC, USA (Temporary Adviser) Dr E.E. Turtle, Pesticides Specialist, Plant Protection Service, FAO, Rome, Italy (Joint Secretary) Dr G. Vettorazzi, Scientist, Food Additives, WHO, Geneva, Switzerland (Joint Secretary) INTRODUCTION A Joint Meeting of the FAO Panel of Experts on Pesticide Residues and the Environment and the WHO Expert Group on Pesticide Residues was held in Rome from 22 to 30 November 1976. The report on the session which is entitled "Report of the 1976 Joint Meeting of the FAO Panel of Experts on Pesticide Residues and the Environment and the WHO Expert Group on Pesticide Residues" provides information on the general principles followed and considerations of the meeting. It also contains a summary of the evaluations made on residues in foods of the various pesticides considered at the session. The present document contains recommendations for acceptable daily intakes, for maximum acceptable residue levels and for methods of analysis together with summaries of the data considered by the Meeting in making these recommendations. As much relevant information as possible has been included in the monographs. This has been obtained from the published literature wherever possible, but other sources of information have also been used. Early and complete publications of the results of research in this field are very important, particularly of that part which could form the basis for estimation of acceptable daily intakes and appropriate residue levels. Publication allows the research to be scrutinized and criticized by scientists from disciplines not necessarily represented at the meeting. Data contained in unpublished reports is less satisfactory and, when considered, must be complete and nonconfidential and indicate authorship. Some of the compounds considered at this meeting have been previously evaluated and reported on in earlier publications. If only a limited amount of additional information of these compounds has become available at this meeting, only this latter information is summarized in the pertinent monograph, and reference is made to the previously published evaluation, which should also be consulted by the reader who wishes to obtain a complete evaluation of the compound. Such monograph addenda are indicated by an asterisk in the "Contents", p. iii. The Annex at the end of this volume of monographs is a reproduction of Annex I of the Report of the 1976 Joint Meeting and gives a summary of the recommendations concerning acceptable daily intakes, residue limits and guideline levels recommended at the 1976 Meeting. NOTE TO THE READER Any comments on evaluation for acceptable daily intake should be addressed to: Food Additives Unit World Health Organization Geneva, Switzerland Any comments on residues in food and their evaluation should be addressed to: Plant Protection Service Plant Production and Protection Division Food and Agriculture Organization Rome, Italy
See Also: Toxicological Abbreviations