WHO Pesticide Residues Series. No. 2
1972 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD
THE MONOGRAPHS
The evaluations contained in these monographs were prepared by the
Joint Meeting of the FAO Working Party of Experts on Pesticide
Residues and the WHO Expert Committee on Pesticide Residues that met
in Rome from 20 to 28 November 1972.1
World Health Organization
Geneva
1973
1 Pesticide Residues in Food: Report of the 1972 Joint Meeting of
the FAO Working Party of Experts on Pesticide Residues and the WHO
Expert Committee on Pesticide Residues, Wld Hlth Org. techn. Rep.
Ser., 1973, No. 525; FAO Agricultural Studies, 1973, No. 90.
These monographs are also issued by the Food and Agriculture
Organization of the United Nations, Rome, as document AGP:1972/M/9/1.
(c) FAO and WHO 1973
CONTENTS
List of Attendees
Introduction
The Monographs
Azinphos-methyl
Bromophos
Bromophos-ethyl
Carbophenothion
Chlordane*
Chlormequat*
Chlorobenzilate*
Chloropropylate*
Chlorpyrifos
Coumaphos*
Crufomate*
Dioxathion*
Diquat*
Ethion*
Fenchlorphes*
Fensulfothion
Fentin Compounds*
Formothion*
Methidathion
Mevinphos*
Monocrotophos
Paraquat*
Parathion-methyl*
Phosalone
Phosphamidon*
Piperonyl butoxide*
Pyrethrins*
Thiabendazole
Annex 1 - Index to documentation and summary of recommendations
concerning acceptable daily intakes, tolerances, and practical residue
limits, as of December 1972
ANNEX 2 - References
* Addendum
LIST OF ATTENDEES
Members of the FAO Working Party of Experts on Pesticide Residues:
Dr. D.C. Abbott, Senior Superintendent, Environmental Chemistry,
Laboratory of the Government Chemist, Department of Trade and
Industry, London, England
Dr. A.F.H. Besemer, Head, Pesticides Division, Plant Protection
Service, Ministry of Agriculture, Wageningen, Netherlands
Dr. K. Glogowski, Deputy Director (Scientific), Plant Protection
Institute, Posnan, Poland
Dr. K.R. Hill, US Department of Agriculture, Analytical Chemistry
Laboratory, Agricultural Environmental Quality Institute - ARS,
Beltsville, Md., USA (Chairman)
Dr. P.E. Koivistoinen, Director, Institute of Food Chemistry and
Technology, University of Helsinki, Finland
Mr. J.T. Snelson, Pesticides Co-ordinator, Department of Primary
Industry, Canberra, Australia (Rapporteur)
Members of the WHO Expert Committee on Pesticide Residues:
Dr. W.F. Almeida, Director, Division of Animal Biology, Biological
Institute, Sao Paulo, Brazil
Dr. V. Benes, Chief, Division of Toxicology and Reference Laboratory,
Institute of Hygiene and Epidemiology, Prague, Czechoslovakia
Mr. D.J. Clegg, Head, Pesticide Unit, Division of Toxicology, Food
Advisory Bureau, Health Protection Branch, Ottawa, Ontario, Canada
(Rapporteur)
Dr. S.D. Murphy, Associate Professor of Toxicology, Harvard
University, School of Public Health, Boston, Mass., USA
Professor I. Nir, Head, Department of Clinical Pharmacology, Ministry
of Health, Jerusalem, Israel
Dr. H.G. Verschuuren, Head, Department of Biological Toxicology of
Pesticides, National Institute of Public Health, Bilthoven,
Netherlands (Vice-Chairman)
Secretariat:
Dr. R.L. Baron, Environmental Protection Agency, Perrine Primate
Laboratory, Perrine, Fla., USA (Consultant)
Dr. L. Ladomery, Food Standards Officer, Food Standards Branch
(FAO/WHO Programme) International Agency Liaison Division, FAO, Rome,
Italy
Dr. F.C. Lu, Chief Scientist, Food Additives, WHO, Geneva, Switzerland
(Joint Secretary)
Dr. H. Marchart, Pesticide Residue and Pollution Section, Joint
FAO/IAEA Division of Atomic Energy in Agriculture, Vienna, Austria
Dr. M. Sharratt, Senior Medical Officer, Department of Health and
Social Security, London, England (Consultant)
Mrs. K. Tedesco-Zammarano, Plant Protection Service, FAO, Rome, Italy
Dr. L. Tomatis, Chief Chemical Carcinogenesis Unit, International
Agency for Research on Cancer, Lyon, France
Dr. E.E. Turtle, Pesticides Specialist, Plant Protection Service, FAO,
Rome, Italy (Joint Secretary)
Dr. G. Vettorazzi, Scientist, Food Additives, WHO, Geneva, Switzerland
INTRODUCTION
A Joint Meeting of the FAO Working Party of Experts on Pesticide
Residues and the WHO Expert Committee on Pesticide Residues was held
in Rome in November, 1972. The general considerations, including the
principles adopted for the evaluations and a summary of the results of
evaluations on a number of pesticide residues, appear in the
publication, "Report of the 1972 Joint Meeting of the FAO Working
Party of Experts on Pesticide Residues and the WHO Expert Committee on
Pesticide Residues".2 Additional information, including previously
unpublished summaries of data considered by the Joint Meeting in
arriving at recommendations for acceptable daily intakes, tolerances
and methods of analysis, is to be found in this document.
Many of the compounds considered at this meeting have been previously
evaluated in earlier publications. If only a limited amount of
additional information on these compounds has become available in the
intervening years, only this latter information is summarized in the
pertinent monograph, and reference is made to the previously published
evaluation, which should also be consulted by the reader who wishes to
obtain a complete evaluation of the compound. Such monograph addenda
are indicated by an asterisk in the "Contents", p. iii. If a large
amount of data has become available since the previously published
evaluation, or if the compound was first considered by the Joint
Meeting in 1972, the pertinent monograph is reproduced in its
entirety.
As much relevant information as possible has been included in the
monographs. This has been obtained from the published literature
wherever possible, but other sources of information have also been
used. Early and complete publication of the results of research in
this field is very important, particularly of that part which could
form the basis for estimation of acceptable daily intakes and
appropriate tolerances.
Publication allows the research to be scrutinized and criticized by
scientists from disciplines not necessarily represented at the
meeting. Data contained in unpublished reports, because they may
include more detail than published work, are often acceptable.
However, such reports must be complete and nonconfidential and
indicate authorship.
2 Pesticide residues in food. Report of the 1972 Joint Meeting of the
FAO Working Party of Experts on Pesticide Residues and the WHO Expert
Committee on Pesticide Residues, WHO Technical Report Series No. 525,
FAO Agricultural Studies, No. 90.
Two appendices have been included at the end of this series of
monographs. Appendix I is a reproduction of Appendix I in the Report
of the 1972 Joint Meeting,3 and gives the source of all the previous
monographs of various compounds. Appendix II gives bibliographic data
of a general nature.
NOTE TO THE READER
Any comments on residues in food and their evaluation should be
addressed to:
Plant Protection Service
Plant Production and Protection Division
Food and Agriculture Organization
Rome, Italy
Any comments on evaluation for acceptable daily intakes should be
addressed to:
Food Additives Unit
World Health Organization
Geneva, Switzerland
3 Pesticide residues in food. Report of the 1972 Joint Meeting of the
FAO Working Party of Experts on Pesticide Residues and the WHO Expert
Committee on Pesticide Residues, WHO Technical Report Series, No. 525,
FAO Agricultural Studies, No. 90.