AGP:1970/M/12/1
WHO/FOOD ADD/71.42
1970 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD
THE MONOGRAPHS
Issued jointly by FAO and WHO
The content of this document is the result of the deliberations of the
Joint Meeting of the FAO Working Party of Experts and the WHO Expert
Group on Pesticide Residues, which met in Rome, 9-16 November, 1970.
FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS
WORLD HEALTH ORGANIZATION
Rome, 1971
This document contains summaries of data considered by the Joint
Meeting of the FAO Working Party of Experts and the WHO Expert Group
on Pesticide Residues in arriving at recommendations for acceptable
daily intakes, tolerances and methods of analysis.
A summary Report of the 1970 Joint Meeting 1/ has also been
published which contains general considerations, including the
principles adopted for the evaluations and a summary of the results of
evaluations of a number of pesticide residues.
1/ Pesticide residues in food. Report of the 1970 Joint Meeting of
the FAO Working Party of experts on pesticide residues and the WHO
Expert Group on pesticide residues, WHO Technical Report Series, No.
474, FAO Agricultural Studies, No. 87.
CONTENTS
List of Attendees
Introduction
The Monographs
Carbaryl *
Chlordane *
Chlormequat
2, 4 - D
Diazinon *
Dichlorvos *
Dicofol *
Dieldrin *
Dimethoate *
Diquat
Dithiocarbamate Fungicides *
Endrin *
Ethion *
Fentin Compounds
Heptachlor *
Malathion *
Mancozeb
Paraquat
Parathion *
Pyrethrins *
2, 4, 5 - T
Thiabendazole
Tricyclohexyltin Hydroxide
Appendix I - Index to documentation and summary of
recommendations concerning acceptable daily
intakes, tolerances, and practical residue limits,
as of December 1970
Appendix II - References
Appendix III - Glossary 563
* Addendum
LIST OF ATTENDEES
Members of the FAO Working Party of Experts on Pesticide Residues:
Dr D. C. Abbott, Pesticides and Toxic Gases Division, laboratory of
the Government Chemist, London, England
Dr K. R. Hill, Agricultural Research Service, Entomology Research
Division, US Department of Agriculture, Beltsville, Md., USA
Dr A. H. M. Kirby, East Malling Research Station, East Malling, Kent,
England
Dr P. E. Koivistoinen, Director of Food Chemistry Division, University
of Helsinki, Finland
Mr J. T. Snelson, Pesticide Coordinator, Department of Primary
Industry, Canberra, A.C.T., Australia (Rapporteur)
Dr E. Y. Spencer, Director, Research Institute, Canada Department of
Agriculture, London, Ontario, Canada (Vice-Chairman)
Members of the WHO Expert Committee on Pesticide Residues:
Dr W. F. Almeida, Director, Division of Animal Biology, Biological
Institute, Sao Paulo, Brazil
Dr V. Benes, Chief, Department of Toxicology and Reference Laboratory,
Institute of Hygiene, Prague, Czechoslovakia
Professor F. Coulston, Director, Institute of Experimental Pathology
and Toxicology, The Albany Medical College of Union University,
Albany, N.Y., USA (Chairman)
Dr Y. Omori, Head, Department of Pharmacology, National Institute of
Hygienic Sciences, Setagaya, Tokyo, Japan
Dr E. Poulsen, Director, Institute of Toxicology, National Food
Institute, Soborg, Denmark
Dr F. J. C. Roe, Head, Department of Experimental Pathology, Chester
Beatty Research Institute, Institute of Cancer Research, Royal Cancer
Hospital, London, England (Rapporteur)
Dr H. G. Verschuuren, Head, Department of Biological Toxicology,
National Institute of Public Health, Bilthoven, Netherlands
Secretariat:
Dr R. L. Baron, Chief, Biochemistry and Metabolism Section, Bureau of
Foods and Pesticides, Food and Drug Administration Washington, D.C.,
USA (Consultant)
Dr P. E. Berteau, Scientist, Food Additives, WHO, Geneva, Switzerland
Dr F. C. Lu, Chief Scientist, Food Additives, WHO, Geneva, Switzerland
(Joint Secretary)
Dr L. Tomatis, Chief, Chemical Carcinogenesis Unit, International
Agency for Research on Cancer, Lyons, France
Professor R. Truhaut, Director, Toxicological Research Centre, Faculty
of Pharmacy, University of Paris, France (Consultant)
Dr E. E. Turtle, Pesticides Specialist, Plant Protection Service, FAO,
Rome, Italy (Joint Secretary)
Dr F. W. Whittemore, Senior Officer, Plant Protection Service, FAO,
Rome, Italy
Dr F. P. W. Winteringham, Head, Pesticide Residues and Pollution
Section, Joint FAO/IAEA Division of Atomic Energy in Agriculture,
Vienna, Austria
INTRODUCTION
A Joint Meeting of the FAO Working Party of Experts on Pesticide
Residues and the WHO Expert Committee on Pesticide Residues was held
in Rome in November, 1970. The general considerations including the
principles adopted for the evaluations and a summary of the results of
evaluations on a number of pesticide residues, appear in the
publication, "Report of the 1970 Joint Meeting of the FAO Working
Party of Experts on Pesticide Residues and the WHO Experts Committee
on Pesticide Residues". 1/ Additional information, including
previously unpublished summaries of data considered by the Joint
Meeting in arriving at recommendations for acceptable daily intakes,
tolerances and methods of analysis, is to be found in this document.
Many of the compounds considered at this meeting have been previously
evaluated in earlier publications. If only a limited amount of
additional information on these compounds has become available in the
intervening years, only this latter information is summarized in the
pertinent monograph, and reference is made to the previously published
evaluation, which should also be consulted by the reader who wishes to
obtain a complete evaluation of the compound. Such monograph addenda
are indicated by an asterisk in the "Contents", p. iii. If a large
amount of data has become available since the previously published
evaluation or if the compound was first considered by the Joint
Meeting in 1970, the pertinent monograph is reproduced in its
entirety.
As much relevant information as possible has been included in the
monographs. This has been obtained from the published literature
wherever possible, but other sources of information have also been
used. Early and complete publication of the results of research in
this field is very important particularly of that part which could
form the basis for estimation of acceptable daily intakes and
appropriate tolerances.
Publication allows the research to be scrutinized and criticized by
scientists from disciplines not necessarily represented at the
meeting. Data contained in unpublished reports, because they may
include more detail than published work, are often acceptable,
However, such reports must be complete and nonconfidential and
indicate authorship.
1/ Pesticide residues in food. Report of the 1970 Joint Meeting of
the FAO Working Party of Experts on Pesticide Residues and the WHO
Expert Group on Pesticide Residues, WHO Technical Report Series No.
474, FAO Agricultural Studies No. 87.
Three appendixes have been included at the end of this series of
monographs. Appendix I is a reproduction of Appendix I in the Report
of the 1970 Joint Meeting, 2/ and gives the source of all the
previous monographs of various compounds. Appendix II gives relevant
bibliographic data, Appendix III comprises definitions of terms, which
were included in the Report of the 1969 Joint Meeting. 3/
NOTE TO THE READER
Any comments on residues in food and their evaluation should be
addressed to:
Plant Protection Service
Plant Production and Protection Division
Food and Agriculture Organization
Rome, Italy
Any comments on evaluation for acceptable daily intakes should be
addressed to:
Food Additives Unit
World Health Organization
Geneva, Switzerland
2/ Pesticide residues in food. Report of the 1970 Joint Meeting of
the FAO Working Party of Experts on Pesticide Residues and the WHO
Expert Group on Pesticide Residues, WHO Technical Report Series, No.
474, FAO Agricultural Studies, No. 87.
3/ Report of the 1969 Joint Meeting of the FAO Working Party of
Experts on Pesticide Residues and the WHO Expert Group on Pesticide
Residues, FAO Agricultural Studies, No. 84, WHO Technical Report
Series, No. 458.
See Also:
Toxicological Abbreviations