FAO/PL:1969/M/17/1
WHO/FOOD ADD./70.38
1969 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD
THE MONOGRAPHS
Issued jointly by FAO and WHO
The content of this document is the result of the deliberations of the
Joint Meeting of the FAO Working Party of Experts and the WHO Expert
Group on Pesticide Residues, which met in Rome, 8 - 15 December 1969.
FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS
WORLD HEALTH ORGANIZATION
Rome, 1970
This document contains summaries of data considered by the Joint
Meeting of the FAO Working Party of Experts and the WHO Expert Group
on Pesticide Residues in arriving at recommendations for acceptable
daily intakes, tolerances and methods of analysis.
A summary Report of the 1969 Joint Meeting* has also been published
which contains general considerations, including the principles
adopted for the evaluations and a summary of the results of
evaluations of a number of pesticide residues.
* Pesticide residues in food. Report of the 1969 joint meeting of the
FAO working party of experts on pesticide residues and the WHO expert
group on pesticide residues, FAO Agricultural Studies, No. 84 WHO
Technical Report Series, No. 458
CONTENTS
List of Attendees
Introduction
Note to the reader
The Monographs
Binapacryl
Bromide Ion*
Captafol
Captan
Carbaryl*
Chlordane*
DDT*
Dichlofluanid
Dichlorvos*
Dieldrin*
Dinocap
Diphenylamine
Ethion*
Ethoxyquin
Fenitrothion
Folpet
Formothion
Heptachlor*
Hexachlorobenzene
Hydrogen Phosphide*
Lindane*
Malathion*
Parathion*
2-Phenylphenol and its Sodium Salt
Phosphamidon*
Piperonyl Butoxide*
Pyrethrins*
Quintozene
Thiometon
Appendix I - Index to documentation and summary of recommendations
concerning acceptable daily intakes, tolerances and limits at December
1969
Appendix II - References
Appendix III - Glossary
* Addendum
LIST OF ATTENDEES
Members of the FAO Working Party of Experts on Pesticide Residues:
Dr. D.C. Abbott, Head, Division of Pesticides and Toxic Gases,
Laboratory of the Government Chemist, Cornwall House, Stamford Street,
London, S.E.1, England
Dr. M. Beroza, Investigation Leader (Chemist), US Department of
Agriculture, Agriculture Research Centre, Beltsville, Maryland, USA
Dr. H. Hurtig, Research Coordinator (Pesticides), Research Branch,
Canada Department of Agriculture, Central Experimental Farm, Ottawa,
Ontario, Canada (Chairman)
Dr. A.H.M. Kirby, Head, Plant Protective Chemistry Section, East
Malling Research Station, East Malling, Maidstone, Kent, England
Dr. P. Koivistoinen, Director of Food Chemistry Division, University
of Helsinki, Institute of Food Chemistry and Technology, Vikki,
Helsinki 71, Finland
Mr. J.T. Snelson, Pesticide Coordinator, Department of Primary
Industry, Canberra ACT, Australia (Rapporteur)
Members of the WHO Expert Group on Pesticide Residues:
Professor F. Bär, Director, Division of Toxicology and Nutrition,
Federal Ministry of Health, Bad Godesberg, Federal Republic of Germany
Professor A. Bojanowska, Director, Department of Sanitary Toxicology,
State Institute of Hygiene, Warsaw, Poland
Professor F. Coulston, Director, Institute of Experimental Pathology
and Toxicology, The Albany Medical College of Union University,
Albany, N.Y., USA (Vice-Chairman)
Dr. O.G. Fitzhugh, Toxicological Adviser, Division of Toxicological
Evaluation, Bureau of Science, Food and Drug Administration,
Washington, D.C., USA
Dr. W.A. Mannell, Chief, Division of Toxicology, Bureau of Food
Advisory Services, Food and Drug Directorate, Ottawa, Ontario, Canada
Dr. E. Poulsen, Director, National Food Institute, Institute of
Toxicology, Soborg, Denmark (Rapporteur)
Professor R. Truhaut, Director, Toxicological Research Centre, Faculty
of Pharmacy of the University of Paris, Paris, France
Dr. H.G. Verschuuren, Head, Department of Biological Toxicology,
National Institute of Public Health, Utrecht, The Netherlands
Secretariat:
Dr. P.E. Berteau, Scientist, Food Additives, WHO
Mr. A. Eisenberg, Food Standards Branch, FAO (Consultant)
Dr. F.C. Lu, Chief, Food Additives, WHO (Joint Secretary)
Dr. L. Tomatis, Chief, Unit of Chemical Carcinogenisis, International
Agency for Research on Cancer, Lyon, France
Dr. E.E. Turtle, Head, Chemistry Department, Infestation Control
Laboratory, Ministry of Agriculture, Fisheries and Food, Tolworth,
Surrey, England (Consultant)
Dr. F.W. Whittemore, Chief, Crop Protection Branch, Plant Production
and Protection Division, FAO (Joint Secretary)
Dr. F.P.W. Winteringham, Head, Pesticide Residues and Pollution
Section, Joint FAO/IAEA Division of Atomic Energy in Agriculture,
Vienna
INTRODUCTION
A Joint Meeting of the FAO Working Party of Experts on Pesticide
Residues and the WHO Expert Group on Pesticide Residues was held in
Rome in December 1969. The general considerations, including the
principles adopted for the evaluations and a summary of the results of
evaluations on a number of pesticide residues will appear in a
publication entitled "Report of the 1969 Joint Meeting of the FAO
Working Party of Experts on Pesticide Residues and the WHO Expert
Group on Pesticide Residues".* Additional information, including
previously unpublished summaries of data considered by the Joint
Meeting in arriving at recommendations for acceptable daily Intakes,
tolerances and methods of analysis, is to be found in this document.
Many of the compounds considered at this meeting have been previously
evaluated in earlier publications. If only a limited amount of
additional data on these compounds have become available in the
intervening years, only this latter data are summarized in the
pertinent monograph and reference is made to the previously published
evaluation which should also be consulted by the reader who wishes to
obtain a complete evaluation of the compound. Such monograph addenda
are indicated by an asterisk in the 'Contents', p. (iii). If a large
amount of data has become available since the previously published
evaluation, or if the compound was first considered by the Joint
Meeting in 1969, the pertinent monograph is reproduced in its
entirety.
As much relevant information as possible has been included in the
monographs. Wherever possible this has been obtained from the
published literature, but other sources of information have also been
used. Early and complete publication of the results of research in
this field is very important, particularly of that part which could
form the basis for estimation of acceptable daily intakes and
appropriate tolerances.
Publication allows the research to be scrutinized and criticized by
scientists from disciplines not necessarily represented at the
meeting. Data contained in unpublished reports, because they may
include more detail than published work, are often acceptable.
However, such reports must be complete and non-confidential and
indicate authorship.
Three appendices have been included at the and of this series of
monographs. Appendix I is a reproduction of Appendix I in the Report
of the 1969 Joint Meeting* and gives the source of all the previous
* Pesticide residues in food. Report of the 1969 Joint Meeting of
the FAO Working Party of Experts on Pesticide Residues and the WHO
Expert Group on Pesticide Residues, FAO Agricultural Studies, No. 84,
WHO Technical Report Series, No. 458.
monographs of various compounds and Appendix II gives relevant
bibliographic data. Appendix III comprises a definition of terms, most
of which were included in the Report of the 1968 Joint Meeting.+ Two
additional terms, namely "Conditional Acceptable Daily Intake" and
"Tentative Negligible Daily Intake" are also defined in this Appendix.
NOTE TO THE READER
Any comments on residues in food and their evaluation should be
addressed to:
Plant Protection Service
Plant Production and Protection Division
Food and Agriculture Organization
Rome, Italy
Any comments on evaluations for acceptable daily intakes should be
addressed to:
Food Additives Unit
World Health Organization
Geneva, Switzerland
+ Report of the 1968 Joint Meeting of the FAO Working Party of
Experts on Pesticide Residues and the WHO Expert Committee on
Pesticide Residues, FAO Agricultural Studies, No. 78, WHO Technical
Report Series, No. 417.
See Also:
Toxicological Abbreviations